[Sephiroth]

Originally Posted by 1andrew1

No one's pretending it's a magic bullet. It's a way of getting the R-level down to something manageable. If it has to happen again in the future until we achieve herd immunity through vaccination, I don't see that as a reason for not doing it again.

But nobody's ever found a deployable coronavirus vaccine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177048/

This article is well worth a read. It says that no SARS nor MERS vaccine ever became commercially available.

The conclusion of the study is as follows:

The vaccine development efforts for coronavirus strains such as SARS and MERS can help to direct the vaccine development efforts for COVID-19. The development of highly effective and safe vaccines for COVID-19 should consider aspects such as the possibility of ADE and other adverse effects previously observed with SARS and MERS. Even though these features have only been seen in some animal models and vaccination regimens, the possibility is still there to be considered for COVID-19. In addition, these vaccine development efforts should address the possibility of the short-term immunogenicity derived from neutralizing antibodies, as also previously observed for SARS and MERS-CoV after natural infection.

The possibility of exploiting T cell responses for coronavirus vaccination should also be considered (along with B cell responses). These responses have been shown to be persistent and protective in animal models. Furthermore, there is evidence of long-term persistence in humans. Strategies such as adjuvantation, tailoring of the S glycoprotein, different routes of vaccination and the use of unexplored vaccine platforms for enhancing immunogenicity and preventing potential undesired effects should also be considered. It is worth mentioning that employing the N protein of the coronavirus for vaccination could have several benefits. As previously mentioned, there is the potential of providing long-term cross-protection when employing this antigen. Of note, the evidence of short-term immunogenicity and protection in coronavirus-exposed individuals does not mean that an effective vaccine is not possible. Vaccines for other now eradicated diseases that lack naturally acquired immunity prove this point (e.g., smallpox). The emergence of COVID-19 should also serve for elevating our comprehension and expertise in the abatement of pathogenic microorganisms of global health importance.

The adverse effects of the SARS/MERS vaccine efforts need to be borne in mind for CV and this is why a vaccine would likely take years to be commercially available.

However the article moots that a vaccine that stimulates T-Cell production could be useful.

Repeated lockdown cycles are incompatible with human behaviour and thus we can never eliminate the virus in that way, never mind trashing the economy beyond the point of salvation.

Those who support lockdowns, please explain how this will kill the virus.