The registry does not need scanning everytime you open an app at all because the app has settings in it that places registry entries in specific keys you do not need to scan for something when you already know where it is do you
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Just for point of refference here is a quote from Mark Russinovich Co Founder of Winternals and Sysinternals when asked the question, Do I need registry cleaner?
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No, even if the registry was massively bloated there would be little impact on the performance of anything other than exhaustive searches (ed. of the registry itself).
On Win2K Terminal Server systems, however, there is a limit on the total amount of Registry data that can be loaded and so large profile hives can limit the number of users that can be logged on simultaneously.
I haven’t and never will implement a Registry cleaner since it’s of little practical use on anything other than Win2K terminal servers and developing one that’s both safe and effective requires a huge amount of application-specific knowledge.
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source
http://www.whatthetech.com/2007/11/2...istry-cleaner/
Below is a link to some information from a guy who had an 18 year career as a programmer with Microsoft
http://ask-leo.com/whats_the_best_registry_cleaner.html
Quote:
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I rarely use a registry cleaner. In fact, I've never actually felt that I've needed to use a registry cleaner. And I definitely install and play with random things on my machine on a regular basis.
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Admitedly its dated but the registry is still the registry, I find it hard to find any technical website that actually endorses Reg scans