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Originally Posted by tweetiepooh
Isn't it part of the fun of The Doctor that he does regenerate so different leads, different styles? How about a female lead, doctor wakes up with "different bits" and different hormones?
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I could see them gender flipping the Doctor but I'm not sure they'll do so with a relatively new female companion. I mean there they could both be female but generally the (main) companion is a woman because the Doctor is a man.