Well, it shouldn't cause you anymore trouble than having to format your drive and reinstall Windows!!
I read in another forum that this is what NTL TS suggest if they think your IP stack is borked... (Formatting & reinstalling Windows that is, not the netsh fix)!
[Edit] Microsoft are very cautious, & their only warning is that 3rd party antivirus & firewall programs that access the internet may be affected. If this is the case they should be reinstalled.
---------- Post added at 18:49 ---------- Previous post was at 17:17 ----------
Forgot to say, if there's nothing wrong with the stack the command won't change anything!!