HKEY_LOCAL_MACHINE\ SOFTWARE\ Microsoft\ Windows\ CurrentVersion\ Run
Zsys = %sysdir%\ zsys.exe
where %sysdir% is the Windows system directory
Stuart, do I have to only delete %sysdir% as I cannot find this exact string, I have just down loaded and ran Ad-aware it found 15 problems but on re-boot the nasty was back, how come only Windows defender is the only spy ware programmer to detect it ? I have the other utilities you mentioned but they cannot deal with this problem either !
---------- Post added at 12:58 ---------- Previous post was at 12:56 ----------
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Originally Posted by Tightscot
What about going into msconfig, and turning off everything in the 'startup' section. Then reboot , turning each item back on, one at a time and checking to see if it reinstalls itself. that way you can find what startup entry is causing the reinstall.
Might take a while but may be the best way forward.... 
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Thank you for that if all else fails I will have to go down that route !