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Originally Posted by Gareth
The bog-standard Windows defrag never liked my anti-virus running at the same time as the defrag... only discovered that one after having left the damn thing running overnight and realising it kept restarting itself every fe minutes 
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Defrag won't get on well with most running processes; that's why zinglebarb suggested you run it in safe mode. Defrag should always be run with as little stuff running as possible.