I replaced the HDD on my Toshiba S2450-201. There was a single screw on the bottom which held closed a hatch, underneath was a Hard Drive bracket, again, screwed on by one screw. I undid the screws and parted the Hard Drive bracket containing the HDD of course away from the connection. Laptop HDDs are special 2.5" sized HDDs with 44 pins which carry power and data, it was just a case of parting the hdd away from the connector on the motherboard, removing the HDD from the bracket, removing the HDD from the plastic anti-static wallet it was in, slipping the new drive in, re-attaching the bracket into the laptop, screwing it in and the hatch on and installing Windows.
I bought my new HDD from
www.scan.co.uk it was a 40gb Hitachi Travelstar, any make will do usually.
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P.S.
I bought one of these to rescue the data from the HDD
http://cgi.ebay.co.uk/ws/eBayISAPI.d...771043418&rd=1
and it works great