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Originally Posted by nomadking
Although not an overnight change, I remember the TV programme about a Caribbean Island, where some are born appearing to be female, but later on physically change to male. I think there's a Pacific Island with the same genetic fault.
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There are six karyotypes that can result in a live human birth. The genetically normal ones are XX (female) or XY (male) and result in normal physical development and expression of large gametes (eggs, female) or small gametes (sperm, male), and normal external and internal reproductive anatomy. The other four all result in disorders of sexual development, however the term ‘intersex,’ which has been used to describe them is scientifically incorrect. Every DSD which is capable of resulting in a live human birth produces a human child with either large or small gametes, so biologically either female or male. Their external sex organs may be malformed and may be misidentified by inexperienced medics leading to an incorrect observation of sex at birth. This may come to light at puberty when the sex organs may appear to change from one to the other. However, the individual was born either a biological male or female and remains so despite any changes to their external appearance.