On a site that I frequent, the left mouse button stopped working a couple of weeks ago. No mouse driver problem. Spare mouse has the same problem.
Today, another 2 sites I frequent daily show the same problem. A brand new mouse shows the same problem. Come off the site and try again, the mouse works once out of about 4 reloads.
e.g.
https://www.netweather.tv/live-weather/radar