Quote:
Originally Posted by Paul
You're wasting your time, he will just argue and argue and argue until you get fed up.
Only he is right, no one else, all seeing and all knowing, you should know that by now. 
Now I think about it, he really does remind me of Graham, thanks Chris.  |
I know but I can't help myself, sort of a self flagellation. A morbid curiosity of the diseased mind.
---------- Post added at 18:20 ---------- Previous post was at 18:11 ----------
Quote:
Originally Posted by jfman
On the contrary Pierre it would mean I became further distracted by speculative nonsense.
We've real world, observed analysis of this coronavirus and it's variants.
If they were all much of a muchness as your simplistic hypothesis suggests then no such observations would take place and, in all likelihood, vaccines would perform roughly the same. It's all T cell and B cell immunity after all, innit?
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Not my hypothesis.
Quote:
hCoV Cross-Reactive T Cell Memory
There is now also evidence that pre-existing T cell immunity to common cold coronaviruses can prime the response to SARS-CoV-2. Using functional validation of predicted epitopes when arranged in epitope “megapools” and using PBMCs derived from convalescing COVID-19 cases, Grifoni et al. (49) recently reported that all patients studied consistently generated a substantial CD4+/CD8+ T cell response against SARS-CoV-2. In terms of total CD4+ T cell response per donor, on average ~50% of the detected response was directed against the Spike protein, and ~50% was directed against the rest of the SARS-CoV-2 ORFeome. More importantly, when the exact same set of experimental techniques were used with blood samples from healthy control donors (collected between 2015 and 2018) substantial cross-reactive coronavirus T cell memory was detected, suggesting cross-reactive T cell recognition between seasonal cold coronaviruses and SARS-CoV-2. All healthy donors were IgG seropositive to HCoV-OC43 and NL63 RBD, to varying degrees, in line with the endemic nature of these viruses (50–54).
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https://www.frontiersin.org/articles...Bu9EUlI5BK5nlY
This is all very new cutting edge stuff, and it goes some way to explaining why there are such varying responses to the Virus, and why so many people seem to be unaffected by it.