Thread: Coronavirus
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Old 18-01-2021, 14:29   #2932
OLD BOY
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Re: Coronavirus
Quote:
Originally Posted by jonbxx View Post
Just catching up on this thread and have seem some vaccine hesitancy here, much like in the larger population. I have seem comments here questioning the safety of the vaccines due to the speed of the roll out, questioning the sample (cohort) size and lack of long term safety information.

The questions I would ask are these;
  • What is a satisfactory cohort size to convince the doubters that a drug is safe?
  • What is the basis on which this number is reached?
  • How long is long enough to judge that there are no long term effects and again, what is this based on?
  • Do doubters look at trial data for other drugs on the market to judge sufficient trial robustness?
  • If not, why not? What is special about this vaccine?
  • Is there still confidence in drug safety evaluation performed by regulatory agencies in light if the speed of approval for COVID vaccines?

This article gives data in table 1 on the cohort sizes for a number of vaccines approved by the FDA from 2000-2011. Some of the cohorts are pretty small! - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551877/
I think the major concern is with the RNA vaccines, like Phizer. I am satisfied that the immediate short term effects are minimal, and in most non-existent, but the issue relates to the longer term impacts, particularly given that this is a completely different kind of vaccine which involves injection of the virus’ DNA.

The testing of the vaccination over less than a year will not reveal longer term side-effects, whereas over the normal period of 10 years or so, testing is more likely to pick this up.

The vaccination could be completely safe - safer in fact than older style vaccines - but the point is, we don’t know that. Even with the rigour that has been deployed before, vaccines have had to be withdrawn urgently due to longer term effects that were not known when the vaccine was released. The SARS vaccine, which induced narcolepsy in a significant number of recipients, is a case in point.

It is for these reasons that I would only be prepared to take the Oxford AstraZenica vaccine at the present time, which I believe to be the safer, more conventional inoculation. We have ample supplies of that coming on stream, fortunately.
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