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Originally Posted by Sephiroth
Excellent document. I found, as a layman, the following texts to be informative from my particular aspect:
(page 3311 = 4/18)
(Page 3321 = 14/18)
Maybe an oversimplification - but this tells me that genuinely it is not known the degree to which the vaccines can deal with other coronaviruses and imo, it tends to the negative depending on the precise binding opportunities for any specific virus and the cells to which they prefer to bind.
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It is a very good paper and probably published in too low a journal though the Journal of Molecular Biology is nothing to be sniffed at.
One of the big take homes is that the amino acid sequences are quite different in the important parts but they seem to have the same function. In relation to your question and conclusion, you are right that it is fairly unlikely that a COVID vaccine would protect against SARS at least.
One thing to look out for are areas that differ little (conserved). If a part of a protein is well conserved across multiple virus (or any other living thing) then it means that they are important and any changes to them will kill of the virus. I worked in a bacterial protein that was 89% similar to a human one. It was involved in DNA repair which is hugely important. If they are so important that they are conserved, then they are a drug target as resistance is tough to develop through mutations.