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Re: U.S Election 2020
Trump also receiving dexamethasone for COVID.
https://www.bbc.co.uk/news/live/world-54382914
BBC article from June 2020.
https://www.bbc.co.uk/news/health-53077879
Quote:
Coronavirus: What is dexamethasone and how does it work?
Coronavirus infection triggers inflammation as the body tries to fight it off.
But sometimes the immune system goes into overdrive and it's this reaction that can prove fatal - the very reaction designed to attack infection ends up attacking the body's own cells.
Dexamethasone calms this effect.
It's only suitable for people who are already in hospital and receiving oxygen or mechanical ventilation - the most unwell.
The drug does not work on people with milder symptoms, because suppressing their immune system at this point would not be helpful.
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Just looked up the BMJ paper on Dexamethasone in the management of covid -19, from July 2020.
Quote:
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Patients admitted to hospital with covid-19 typically report symptom onset three to five days after exposure (fatigue, chills), progressing to fever and dry cough 48 hours later. Transition to severe disease with hypoxaemia occurs five to seven days into the symptomatic illness, about 8-14 days after original exposure. In the RECOVERY trial, dexamethasone was beneficial for participants treated seven or more days into the symptomatic phase, with the onset of hypoxaemia. Importantly, there was a non-significant trend (P=0.14) towards possible harm affecting participants without hypoxaemia and not on mechanical ventilation. RECOVERY findings therefore support use of dexamethasone only for patients with hypoxaemia, not those with milder disease. The data do not support use of dexamethasone or other corticosteroids in the outpatient setting.
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From the US Government National Institutes of Health Medical Research site
Quote:
Recommendations for Patients with COVID-19
- On the basis of the preliminary report from the RECOVERY trial, the COVID-19 Treatment Guidelines Panel (the Panel) recommends using dexamethasone 6 mg per day for up to 10 days or until hospital discharge, whichever comes first, for the treatment of COVID-19 in hospitalized patients who are mechanically ventilated (AI) and in hospitalized patients who require supplemental oxygen but who are not mechanically ventilated (BI).
- The Panel recommends against using dexamethasone for the treatment of COVID-19 in patients who do not require supplemental oxygen (AI).
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Last edited by Hugh; 04-10-2020 at 17:56.
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