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Re: can any tune up software do damage.
Definitely, though CCleaner is usually pretty safe.
Registry cleaning is potentially dangerous, in the battle to be seen to "do something", they may remove entries that are not being used YET!
The best boost for registry, is not "cleaning", but compaction - closing up the gaps left by deletions and alterations, removing internal fragmentation, then removing external fragmentation with a disk defrag that can do boot time defrag to do registry & pagefile etc.
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