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Re: Doctor Who : Season 7
As BenMcr said, both questions have been answered in the series.
River was Amy and Rory's daughter, but because she was conceived in the TARDIS her DNA was mutated by the time vortex to be like a Time Lord's.
Clara was a normal human girl... but when she stepped into the Doctor's timeline scar thing inside his tomb it scattered her across his timeline and enabled her to fix all the things that the Great Intelligence had messed with, which is why the Doctor had already met versions of her on the Dalek Asylum and Victorian London.
No mention or even hint of either of them being a living TARDIS.
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