It's a new show on FX. It premiered with South Park. It's a cartoon which is meant to be a horror-comedy. Wikipedia says
Spoiler:
Take New York City, add every horrifying beast, science-fiction freak, and fantasy fairy, shake thoroughly, and you've got Ugly Americans.
This animated horror-comedy series follows one Mark Lilly, social worker at the Department of Integration, as he helps new citizens both human and "other" adapt to hectic life in the Big Apple. There are easier tasks than weaning vampires off of blood, socializing land-whales, and housebreaking werewolves, but Mark is up to the challenge. Between his stressful job, a zombie roommate, and a demon ex-girlfriend, Mark's lucky if he can sneak in a few minutes of sleep. But who can sleep when there's a drop-dead gorgeous Mermaid sitting at the bar?
I'm watching it now and it seems like an excellent show. It's along the lines of Archer I'd say.