In case anyone is interested the Logitech Harmony 555 works perfectly with the V+ Box
It only took about 20 minutes to perform a basic set up but a good while longer to look through all the settings and see what can and can't be done.
One word of advice if you do get one is that when asked the make and model of your STB, just put VirginMedia V+ and not Scientific Atlanta Explorer 8300 (As written on the box) otherwise you will see a lot of buttons on the screen that do not make sense. I'm guessing its based on the US version of the box.
Thoroughly pleased with my purchase and for £45 you can't go wrong.
PS. It even replaces my Media Centre Remote!