Worst: Encephalitis. Often fatal, those it doesn't kill are often left with permanent brain damage (my finger is hovering over the ban button so don't even think about it

)
Weirdest: A pilonidal sinus. Basically, an inflamed hair follicle in your butt crack that can get infected. To get rid of it you have to have an operation which involves having part of your crack sliced open and then sewn back together. Then you can't sit down for a week.