Sounds like you've somehow got yourself a pretty nasty malware infection there. If you can't boot into safe mode then there's not a lot else that you can really try.
You could
try putting the drive into another working machine with up to date AV and Spyware scanners and see if you can clean it that way [Warning: You could end up infecting the other machine this way].
You could
try booting the machine with a live CD of some sort (either Windows based, or Linux) and see if you can scan for/clean the infections that way.
Failing that your best bet would be to completely rebuild the system, to be honest that's what I'd normally recommend in situations like this anyway.
Here's my post from another thread (which was similar to this one) which explains why:
Quote:
Oh, yeah, almost forgot.
My standard advice for this sort of thing is this:
Your machine has probably been compromised, you should now consider whether you can trust it even after you think you have removed the infection. Best practice in this situation is to re-install everything, after completely blanking the drive, from known good/clean media, and to thoroughly scan any media created with the old system before importing any data from it.
Many nasty programs can hide themselves from the operating system, and even subvert anti-virus software to make it appear as though the machine is now 'clean'. You need to be aware of, and consider this, before you decide how to proceed.
As a final precaution (and certainly if it is the only thing that you do), you should also change all passwords for all accounts that you might possibly have accessed from this machine - this is just in case anything on the machine has been storing/transmitting those without your knowledge.
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