[Charlie_Bubble]

The original book and the modern film are very different and neither is particularly impressive.

You think the film is very close to the book except a few minor changes?

Book:

Spoiler: 

He's white; He's in his 40s; He lives in a small town; He listens to classical music; He drives a fairly simple car; He learns all his medical knowledge from library books; His family die from the disease; The dog is a stray; The woman is a vampire; His neighbour and workmate plagues him throughout; The ending isn't sugar-coated.

Film:

Spoiler: 

He's black, in his 30s; He's a Doctor in the army; He lives in New York; He drives a Ford GT & a huge 4WD; He listens to Bob Marley; His family die in a helicopter crash; The dog is his daughters; There's a little kid and a non-vampire woman; There is a typical modern holywood everything must end nicely ending to it.

I can't think how much more different it could have been, except maybe to exclude vampires and everyone being dead!