I was thinking audio from say (for example) youtube or dailymotion and those sites that allow you to hear a sound but not download.... (seriously, it's sometimes not worth the hassle of downloading/ripping a file from these sites where I may only need a sample of a second long....) I'm also a fan of online text to speech engines - some of which do not allow you to download what you want the engine to speak!
If there was the support on the soundcard for 'what you hear' (which there isn't) then it wouldn't be an issue... in fact, today, I've left everything set up (and used it) to do what needs to be done... and I've had a wonderful fault-free afternoon