According to Sky News - there has been a significant development:
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Originally Posted by Sky News
There appears to have been a significant development in the hunt for missing Madeleine McCann, according to Sky News crime correspondent Martin Brunt.
He reports that Portuguese police are said to be focusing on two men and a woman seen with a girl matching her description.
Officers have called a news conference for later today and Madeleine's parents were driven away at speed from their apartment.
Brunt, who's in Portugal, said: "Things are happening, they could be important, there could be a big development.
"I'm also being told that a town or village has been sealed off near Seville in southern Spain. It is not a long journey to get from the Algarve across the border."
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http://news.sky.com/skynews/article/...264945,00.html