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Interestingly:
SPECT neuroimaging in schizophrenia with religious delusions.
Puri BK, Lekh SK, Nijran KS, Bagary MS, Richardson AJ.
MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK.
Functional neuroimaging techniques such as single-positron emission computed tomography (SPECT) and positron emission tomography (PET) offer considerable scope for investigating disturbances of brain activity in psychiatric disorders. However, the heterogeneous nature of disorders such as schizophrenia limits the value of studies that group patients under this global label. Some have addressed this problem by considering schizophrenia at a syndromal level, but so far, few have focussed at the level of individual symptoms. We describe the first neuroimaging study of the specific symptom of religious delusions in schizophrenia. 99mTc HMPAO high-resolution SPECT neuroimaging showed an association of religious delusions with left temporal overactivation and reduced occipital uptake, particularly on the left.
and:
The serotonergic system and mysticism: could LSD and the nondrug-induced mystical experience share common neural mechanisms?
Goodman N.
Bioelectrostatics Research Centre, Electronics and Computer Science, University of Southampton, United Kingdom.
This article aims to explore, through established scientific research and documented accounts of personal experience, the similarities between religious mystical experiences and some effects of D-lysergic diethylamide or LSD. LSD predominantly works upon the serotonergic (serotonin-using neurons) diffuse neuromodulatory system, which projects its axons to virtually all areas of the brain including the neocortex. By its normal action it modulates awareness of the environmental surroundings and filters a high proportion of this information before it can be processed, thereby only allowing the amount of information that is necessary for survival. LSD works to open this filter, and so an increased amount of somatosensory data is processed with a corresponding increase in what is deemed important. This article describes the effects and actions of LSD, and due to the similarities with the nondrug-induced mystical experience the author proposes that the two could have common modes of action upon the brain. This could lead to avenues of research into mysticism and a wealth of knowledge on consciousness and how we perceive the universe.
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Mystical experience and schizophrenia.
Buckley P.
Autobiographical accounts of acute mystical experience and schizophrenia are compared in order to examine the similarities between the two states. The appearance of a powerful sense of noesis, heightening of perception, feelings of communion with the "divine," and exultation may be common to both. The disruption of thought seen in the acute psychoses is not a component of the accounts of mystical experience reviewed by the author, and auditory hallucinations are less common than visual hallucinations in the mystical state. The ease with which elements of the acute mystical experience can be induced in possession cults or in an experimental situation suggests that the capacity for such an altered state experience may be latently present in many people. It is postulated that there is a limited repertoire of response within the nervous system for altered state experiences such as acute psychosis and mystical experience, even though the precipitants and etiology may be quite different.
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