if you use microsoft outlook then there is a feature to disable 'automatic sender confirmation' which could reduce spam, as it does not send back a confirmation that the email has been recieved.
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Select Options from the Tools menu, click on the E-mail Options button, then click on the Tracking Options button. Make sure that Always send a response is not checked. If it is, uncheck it to stop automatically sending e-mail confirmations to spammers. If you have the automatic response selected, you may be unwittingly verifying your e-mail address to spammers. This tip is specific to Outlook 2003, but similar settings should be found in previous versions of Outlook.
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source: eweek
http://www.eweek.com/article2/0,1759,1547601,00.asp