Originally Posted by Rough.D

Hi this might help

This article was previously published under Q186978

SYMPTOMS
When you use the Disk Defragmenter tool to defragment your hard disk, you may receive the following message:

Drive's Contents Have Changed: Restarting...

CAUSE

This issue can occur if a program (such as an antivirus program or a screen saver) is running on the drive when the Disk Defragmenter tool is running.
RESOLUTION
To work around this issue, use one of the following methods.
Clean Boot the Computer
A "clean" boot is a method of reducing problems that may occur because of your computer's environment. Many problems that may occur when you run Windows or other programs can occur because there are conflicting drivers, terminate-and-stay-resident programs (TSRs), or other settings that load when you start your computer. Windows Millennium Edition (Me) and Windows 98 include a System Configuration Utility tool (Msconfig.exe) to make performing a clean boot easier. To clean boot your computer:
Click Start, point to Programs, point to Accessories, point to System Tools, and then click System Information.
On the Tools menu, click System Configuration Utility.
On the General tab, click Selective Startup, and then click to clear the following check boxes:

Process Config.sys File (if available)
Process Autoexec.bat File (if available)
Process Winstart.bat File (if available)
Process System.ini File
Process Win.ini File
Load Startup Group Items


Click OK, and then restart your computer when you are prompted.
After your computer starts, run the Disk Defragmenter tool. After Disk Defragmenter finishes, start the System Configuration Utility tool again by repeating the above steps. In step 3, click Normal Startup on the General tab, and then click OK. Restart your computer when you are prompted to do so.


You might want to try this instead

Use Safe Mode

Instead of performing a clean boot, you may want to restart your computer in Safe mode, and then start the Disk Defragmenter tool. After you run Disk Defragmenter, restart your computer. To use Safe mode, restart your computer, press and hold down the CTRL key after your computer completes the Power On Self Test (POST), and then choose Safe Mode from the Startup menu.


R.D.