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Originally Posted by stuartbe
Some programs do store files in there. If there is anything running that needs the files it will simply tell you that the file is in use and cant be deleted.
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...so it's best to do it at startup before anything can start putting files there which are in use.
You can't do any damage deleting files from the temp folders.
Let that be a warning to any business users who think it's a good idea to save their files in the temp folder!