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Originally Posted by mixteus
No joy!
I can right click file and change to "open with" Wordpad but it will not play ball with Notepad. 
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Drastic I know but sounds like best bet is a full format and re-install of Windows.
The source of this problem was almost certainly a worm and at the end of the day starting from scratch may be the quickest as well as safest route.
BTW should you go down this route make sure you have a backup copy of the main MSBlaster patch so that can be applied before reconnecting to the net after the re-install.