You could get slide mounts for your hard drives and bay. Then you can shut down, change hard disk dead easy, then power up again. If the bios HD detection is set to auto then you don't need to do anything else.
The beauty of this is that if you ever get a second PC then you can just shove one of the drives in that and start using the o/s that's on it right away with the minimum of fuss.
OK its not ideal in every circumstance but its an another option.
