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Pierre 20-03-2021 20:00

Re: Coronavirus
 
The EU approach to the vaccine issue is like the EU turning up at the AZ butcher on Christmas eve morning and ordering 90 turkeys...............


EU - "Our French supplier hasn't got any so we're short"

AZ - "We'll do our best but were not geared up to give you all 90."

EU - "Well you're supplying Britain?"

AZ - "Yes but they ordered 5 months ago and helped build the farm. We can give you what we've got, maybe 30"

EU- "But we didn't know if it worked 5 months ago"

AZ - "Neither did the UK but they had faith in their science and invested money on behalf of the world"

EU - "Well I'll sue you then...and tell everyone your turkeys are poisonous"

Later that day...

EU - "Sorry about that, your turkeys are fine but now no one wants your turkey. However even though we've got 7 spare at home, we still demand the 90 turkeys, oh and by the way this isn't our fault"

nomadking 20-03-2021 20:25

Re: Coronavirus
 
The EU should recognise that where a product is supplied in two parts, specially with a time constraint on it's supply, then the supplier is contractually obliged to supplied the 2nd part, once it has delivered the 1st part. Pfizer need to supply the UK with the required 2nd doses.

Perhaps the UK could reassure the EU, that any Pfizer vaccine supplied will only initially only be used for 2nd doses.

Hom3r 21-03-2021 10:29

Re: Coronavirus
 
On Friday I booked my first Jab, which I will get Monday morning at 9:20am, best of all its a 5 minute drive away.

Chris 21-03-2021 14:26

Re: Coronavirus
 
Quote:

Originally Posted by Mr K (Post 36058462)
Just a shame we've made the isolationist choices we've made over the past few years. This is a classic example on why acting together with other countries makes us stronger. On our own we're weaker and vulnerable in the marketplace.

I was browsing back through this thread this afternoon and came across this absolute nugget, from the mid-November days when the first vaccine trials results started coming through and we all started looking closely at what the UK and EU had in their preorder portfolios. At issue here was the fact that the EU had preordered from Moderna and we hadn’t.

How I LOLed. :rofl:

pip08456 21-03-2021 15:05

Re: Coronavirus
 
Quote:

Originally Posted by Chris (Post 36074914)
I was browsing back through this thread this afternoon and came across this absolute nugget, from the mid-November days when the first vaccine trials results started coming through and we all started looking closely at what the UK and EU had in their preorder portfolios. At issue here was the fact that the EU had preordered from Moderna and we hadn’t.

How I LOLed. :rofl:

A classic example of Mr K's insight.

Mad Max 21-03-2021 16:03

Re: Coronavirus
 
Quote:

Originally Posted by TheDaddy (Post 36074866)
It's almost the exact opposite of everything you've said, highly irresponsible, negligent and with potential consequences for not only their country but the entire planet

Spot on.

Mick 21-03-2021 22:24

Re: Coronavirus
 
Quote:

Originally Posted by Pierre (Post 36074869)
The EU approach to the vaccine issue is like the EU turning up at the AZ butcher on Christmas eve morning and ordering 90 turkeys...............


EU - "Our French supplier hasn't got any so we're short"

AZ - "We'll do our best but were not geared up to give you all 90."

EU - "Well you're supplying Britain?"

AZ - "Yes but they ordered 5 months ago and helped build the farm. We can give you what we've got, maybe 30"

EU- "But we didn't know if it worked 5 months ago"

AZ - "Neither did the UK but they had faith in their science and invested money on behalf of the world"

EU - "Well I'll sue you then...and tell everyone your turkeys are poisonous"

Later that day...

EU - "Sorry about that, your turkeys are fine but now no one wants your turkey. However even though we've got 7 spare at home, we still demand the 90 turkeys, oh and by the way this isn't our fault"

They are corrupt to the core and a pathetic con job organisation. 17.4 Million still make me proud.

jfman 22-03-2021 08:17

Re: Coronavirus
 
Quote:

Originally Posted by TheDaddy (Post 36074866)
It's almost the exact opposite of everything you've said, highly irresponsible, negligent and with potential consequences for not only their country but the entire planet

I don’t really see how that can be true. It’s not an absolute ban it’s simply moving as emerging data improves. If we are truly interested in the “entire planet” we should remove the IP rights on all vaccines and get production ramped up. Otherwise a time delay on subset of the population in France is likely to have negligible impact on the global response or inevitable emergence of vaccine resistant mutations.

However some good news that should finally end the uncertainty is the outcome of the Phase 3 US clinical trials showing 79% efficacy. While not one to necessarily trust the BBC quick fire analysis the published data should let more independent sources crunch the numbers.

Damien 22-03-2021 09:26

Re: Coronavirus
 
The USA says AZ is a-ok: https://www.bbc.co.uk/news/health-56479462

Quote:

Results from the long-awaited US trial of the Oxford-AstraZeneca Covid vaccine are out and confirm that the shot is both safe and highly effective.

More than 32,000 volunteers took part, mostly in America, but also in Chile and Peru.

The vaccine was 79% effective at stopping symptomatic Covid disease and 100% effective at preventing people from falling seriously ill.

And there were no safety issues regarding blood clots.

That should further reassure some EU countries that recently paused rollout of the vaccine amid concerns about a possible link.
They're asking for FDA approval.

nomadking 22-03-2021 10:09

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36074948)
I don’t really see how that can be true. It’s not an absolute ban it’s simply moving as emerging data improves. If we are truly interested in the “entire planet” we should remove the IP rights on all vaccines and get production ramped up. Otherwise a time delay on subset of the population in France is likely to have negligible impact on the global response or inevitable emergence of vaccine resistant mutations.

However some good news that should finally end the uncertainty is the outcome of the Phase 3 US clinical trials showing 79% efficacy. While not one to necessarily trust the BBC quick fire analysis the published data should let more independent sources crunch the numbers.

Where is your evidence that a block on IP rights is being imposed and is causing delays? For the AZ vaccine, the only requirement that might be a sticking point, is that it has to be supplied at cost.
The EU is threatening to hijack IP rights, but then what? They would still need to build and set up any manufacturing sites, and that takes time. Are they planning to produce AZ vaccine for a profit?

jfman 22-03-2021 11:03

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36074958)
Where is your evidence that a block on IP rights is being imposed and is causing delays? For the AZ vaccine, the only requirement that might be a sticking point, is that it has to be supplied at cost.
The EU is threatening to hijack IP rights, but then what? They would still need to build and set up any manufacturing sites, and that takes time. Are they planning to produce AZ vaccine for a profit?

I wasn't referring to the EU specifically but it stands to reason that if anyone could manufacture any of the vaccines it would ramp up production.

While there would be some scope for unscrupulous profiteering in the short term as supply ramped up to meet demand this would be limited.

My only point was that limiting who can (and where) a vaccine can be manufactured creates supply side blocks. Even when the UK, EU and USA have all been vaccinated we are some considerable distance from the "entire planet" being vaccinated which was the point I was addressing about delays in the French under 55s being vaccinated.

nomadking 22-03-2021 11:37

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36074961)
I wasn't referring to the EU specifically but it stands to reason that if anyone could manufacture any of the vaccines it would ramp up production.

While there would be some scope for unscrupulous profiteering in the short term as supply ramped up to meet demand this would be limited.

My only point was that limiting who can (and where) a vaccine can be manufactured creates supply side blocks. Even when the UK, EU and USA have all been vaccinated we are some considerable distance from the "entire planet" being vaccinated which was the point I was addressing about delays in the French under 55s being vaccinated.

Many countries do produce vaccines. Where is your evidence that anybody is being blocked from using any IP?
The EU has set up new sites and expanded existing ones. Their problem is they left it too late and/or are for vaccines not yet approved.
The world's third biggest vaccine maker, Sanofi of France, came up with duds. That will have delayed EU production massively. That was the "luck of the draw". AZ vaccine might have turned out to be a dud, as with Pfizer, Moderna, etc.

jfman 22-03-2021 11:59

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36074964)
Many countries do produce vaccines. Where is your evidence that anybody is being blocked from using any IP?
The EU has set up new sites and expanded existing ones. Their problem is they left it too late and/or are for vaccines not yet approved.
The world's third biggest vaccine maker, Sanofi of France, came up with duds. That will have delayed EU production massively. That was the "luck of the draw". AZ vaccine might have turned out to be a dud, as with Pfizer, Moderna, etc.

I'm not sure the point you are arguing to be honest.

Clearly the manufacturers are holding exclusive rights over their own vaccines. This isn't surprising - it's industry standard.

Nobody can just open a plant in India, China or elsewhere and start making the vaccines at cost without infringing on the rights of Pfizer, Astrazenica, Moderna or anyone else who has a successful vaccine candidate.

nomadking 22-03-2021 12:26

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36074968)
I'm not sure the point you are arguing to be honest.

Clearly the manufacturers are holding exclusive rights over their own vaccines. This isn't surprising - it's industry standard.

Nobody can just open a plant in India, China or elsewhere and start making the vaccines at cost without infringing on the rights of Pfizer, Astrazenica, Moderna or anyone else who has a successful vaccine candidate.

You stated "If we are truly interested in the “entire planet” we should remove the IP rights on all vaccines and get production ramped up.". What difference would that make unless there has been a block on somebody producing it?
It takes time to expand an existing plant or open a new one. Eg Some French investment of June 2020 has yet to come online.

The UK benefited from government investment in vaccine production before last year. We got ahead of the game.
Link

Quote:

In 2018, UKRI announced £66 million for the UK’s first dedicated Vaccine Manufacturing Innovation Centre (VMIC). The goal was to promote, develop and accelerate the growth of the UK vaccine industry.
Also in 2018, the Vaccine Manufacturing and Research Centre was established by the Engineering and Physical Sciences Research Council (EPSRC).
This was to find new ways to support vaccine manufacturing and delivery in low and middle income countries.
Alongside these landmark projects, UKRI funded many others to ensure the UK would have the capability to manufacture and distribute a vaccine when the time came.

jonbxx 22-03-2021 12:45

Re: Coronavirus
 
The word we are discussing here is Biosimilars. Which are 'generic' biological drugs. Freeing up the IP would create a big biosimilar market. A lot of countries such as India, Gulf states, Brazil, Turkey, South Africa are getting big into biosimilars.

There are some issues with skills. If you look at countries who do a lot of pharmaceutical work, you tend to find the companies are quite bunched together. Ireland is a great example with LOADS of companies based around Dublin and Cork. Ireland invested heavily some years back to grow a pharmaceutical industry through targeted education and big tax breaks. There is now a critical mass of educated people in Ireland who tend to flit from company to company and Ireland is an attractive country to set up shop now.

Countries need to grow that skills base or buy it in. India is growing it, the gulf states are buying it in.

One big reason why companies won't release their IP for these vaccines is that the technology can be very useful once known. Once you know how to modify and produce an adenovirus or mRNA vaccine for one disease, it takes no time to make a different vaccine. This is how the AZ and Pfizer vaccines came out so quick. Knowing how to make a vaccine quickly is great but you wouldn't want to spread that around too much.

jfman 22-03-2021 12:48

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36074973)
You stated "If we are truly interested in the “entire planet” we should remove the IP rights on all vaccines and get production ramped up.". What difference would that make unless there has been a block on somebody producing it?
It takes time to expand an existing plant or open a new one. Eg Some French investment of June 2020 has yet to come online.

The UK benefited from government investment in vaccine production before last year. We got ahead of the game.
Link

I’m still not sure what that has to do with the point I’ve made.

It does indeed take time to expand plants and capacity. Which is why more people doing it would be beneficial.

There is a block on anyone other than the candidate vaccine manufacturers (or anyone doing so under licence) from producing any of their own vaccines. As I say it’s industry standard.

Hugh 22-03-2021 13:19

Re: Coronavirus
 
Interesting thread (imho) on the history of this debacle

https://twitter.com/DaveKeating/stat...577761803?s=20

Quote:

Dave Keating @DaveKeating

I keep seeing the line 'EU is having vaccine problems because it was too slow in negotiating contracts' repeated in Flag of United Kingdom&Flag of United States media.

I want to push back on this narrative because I think it's missing where real EU-level mistakes lie. Let's review what happened in past year

AstraZeneca signed purchasing agreement with EU one day before its agreement with UK.

AZ CEO told an EP hearing last month that UK priority comes from research funding agreement Oxford signed with UK gov in Jan/Feb 2020, inherited by AZ when it partnered with Oxford in May 2020.

United Kingdom was smart to start funding vax research before #Covid19 even hit Europe. But they made a consequential choice by (apparently) making funding conditional to Brits getting doses of any resulting vaccine 1st.

Germany funded BioNTech but did not include any Europe 1st clause.

Meanwhile in March 2020, President Trump tried unsuccessfully to steal BioNTech from Germany to bring it to the US.

Despite this warning, apparently nobody in EU thought it might be a bad idea for BioNTech to be partnered with Pfizer, an American company.

Germany confirms that Trump tried to buy firm working on coronavirus vaccine
CureVac boss was at the White House last week to discuss its vaccines plans.

German nationality-agnostic approach to pharma partners was not the approach used across the channel in the United Kingdom.

Oxford was originally going to partner with American company Merck. But the UK gov overruled it and made them partner with UK-based AstraZeneca

United Kingdom concern over United States vaccine nationalism turned out to be well-founded.

With BioNTech-Pfizer partnership secure, Trump seemed to be in no hurry to sign Pfizer purchase contracts.

Why? He knew a US vaccine export ban would make a contract unnecessary.

Ex-FDA chief confirms administration turned down offer to reserve additional doses of vaccine, set to be first approved for US use

Pfizer has massive production capacity in the US. If US law prevented any of those doses made on US soil from being exported, they would have to go to the US in any event.

The result can be seen in the supply chain. United States plants used to supply United States, European Union plants used to supply Europe & Africa

Sure enough, Trump signed an executive order in December 2020 giving Americans 1st priority to any vaccines made on US territory.

In fact it was largely symbolic. Trump & Biden have instead used the Defence Production Act as the legal basis for their ban.

Also in December 2020, the UK & US used the emergency use authorisation method to approve Pfizer, while the EU used the more cautious conditional marketing approval method, resulting in EU approving 2-3 weeks later.

UK gave emergency use approval to AstraZeneca on 30 December.

When the European Union gave conditional marketing approval to AstraZeneca on 29 Jan, the company informed EU it would not be meeting original dosage delivery promise because of production problems in EU plant. Seems doses to be reserved for the European Union had gone to the United Kingdom

The battle between EU & AZ began

The Commission said AZ signed a contract saying it would use all 4 of its production facilities, 2 in UK and 2 in EU, to deliver to EU - so the shortfall should be made up with exports from the UK.

AZ's CEO said they couldn't because of a 'UK 1st' clause.

Pascal Soriot: "There are a lot of emotions on vaccines in EU. But it's complicated"
An exclusive interview with AstraZeneca's CEO on the accusations from Europe after the delay of Oxford vaccine supplies, some revealing details of the vacc…

That battle has raged on without resolution. AZ will only deliver 30m out of promised 80m for Q1 and 70m of promised 180m in Q2, EC says.

Meanwhile EU has exported 10m (mostly Pfizer) doses to UK, while 'UK 1st' clause stops AZ from meeting EU delivery promise from UK plants.

Across the pond, the US export ban has meant Canada, Mexico, & Japan have to get their Pfizer doses from EU plants instead. (European Union has exported 4.6m doses to Canada, 3.8m to Mexico, 4m to Japan)

Situation particularly absurd for Canada, which must get its Pfizer from Belgium instead of next door in Michigan.

Chris 22-03-2021 13:26

Re: Coronavirus
 
Yay for globalisation and complex supply chains, they turned out to be such a great idea ...

1andrew1 22-03-2021 13:42

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36074964)
Many countries do produce vaccines. Where is your evidence that anybody is being blocked from using any IP?
The EU has set up new sites and expanded existing ones. Their problem is they left it too late and/or are for vaccines not yet approved.
The world's third biggest vaccine maker, Sanofi of France, came up with duds. That will have delayed EU production massively. That was the "luck of the draw". AZ vaccine might have turned out to be a dud, as with Pfizer, Moderna, etc.

The EU did not order any vaccines from GSK-Sanofi. :confused:

Maybe a deal to ease some forms of Indian immigration into the UK in return:
Quote:

Boris Johnson sends envoy to seek vaccine deal with India to ease UK shortage

Prime minister’s fixer Lord Lister will visit Serum Institute where AstraZeneca jab is made

Lister and international adviser David Quarrey met India’s foreign secretary Harsh Shringla in New Delhi on Monday to “discuss bilateral relations and outcomes” for Johnson’s planned visit to the country in April, according to India’s Ministry of External Affairs.

Lister, a Conservative peer and the UK prime minister’s special envoy for the Gulf, is expected to travel from there to Pune where he will visit the Serum Institute of India, the world’s largest vaccine manufacturer and a producer of the AstraZeneca jab, said a person with knowledge of the talks.

“Eddie Lister is making a personal trip on his way to Pune to help resolve this,” the person said. “He[Lister] wants doses but the Indian government is stalling because in parliament they are questioning why are we exporting the vaccines.”

Whitehall insiders confirmed that Lister would visit the Serum Institute this week to try to broker a deal on delivery of the UK’s AstraZeneca doses.
https://www.ft.com/content/0049a35c-...d-e884672298c7

heero_yuy 22-03-2021 17:34

Re: Coronavirus
 
Quote:

Quote from The Sun: Britain would have “no choice” but to block vaccine ingredient exports to the continent if the EU triggers a full blown jab ban, The Sun can reveal.

It came as ministers vowed the UK is still on course to hit vaccine targets and Downing Street is currently confident there will be no backsliding on the road map to freedom - despite the growing war of words with Brussels.

But privately ministers warn Britain will have to retaliate if the EU blocks imports from the continent coming here.

One senior member of the government told The Sun today “politically and morally it's a no brainer” adding that “the British public would not put up” with anything else.

And today the two sides inched closer to a vaccine war after Angela Merkel swatted away the PM's pleas to step back from the brink.
The EU would be the big looser here as the Pfizer vaccine is dependent upon supplies of a critical component from the UK as they've bad-mouthed the AZ one.

Mr K 22-03-2021 17:42

Re: Coronavirus
 
Still a load of Nationalist tripe and politicians trying to play it for themselves. The virus and it's variants don't care about petty politics. No country is immune in the long run if the virus isn't tackled everywhere and we don't work together and share resources/vaccines.

As ever, together we win, divided we lose. Humanity will never learn, which will lead to our ultimate downfall, whether it's a virus or more likely climate change.

Sephiroth 22-03-2021 17:51

Re: Coronavirus
 
Quote:

Originally Posted by Mr K (Post 36075007)
Still a load of Nationalist tripe and politicians trying to play it for themselves. The virus and it's variants don't care about petty politics. No country is immune in the long run if the virus isn't tackled everywhere and we don't work together and share resources/vaccines.

As ever, together we win, divided we lose. Humanity will never learn, which will lead to our ultimate downfall, whether it's a virus or more likely climate change.

If both sides are willing to play the way you recommend, then fine. But if the EU wanted to cooperate, it wouldn't be behaving so badly now.

If we'd joined forces with the EU as you suggested, we'd be right up shit street nix paddle.

1andrew1 22-03-2021 18:54

Re: Coronavirus
 
Quote:

Originally Posted by heero_yuy (Post 36075005)
The EU would be the big looser here as the Pfizer vaccine is dependent upon supplies of a critical component from the UK as they've bad-mouthed the AZ one.

We all lose in such situations but AstraZeneca gets over 70% of its vaccine ingredients from the EU. In contrast, we supply the EU with just 17% of the ingredients used to make its vaccines.

The UK is indeed one of the suppliers for the Pfizer vaccine (lipid nanoparticles) but Merck now also produces the same ingredient in the EU.

https://cadmus.eui.eu//handle/1814/70363

nomadking 22-03-2021 19:16

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075028)
We all lose in such situations but AstraZeneca gets over 70% of its vaccine ingredients from the EU. In contrast, we supply the EU with just 17% of the ingredients used to make its vaccines.

The UK is indeed one of the suppliers for the Pfizer vaccine (lipid nanoparticles) but Merck now also produces the same ingredient in the EU.

https://cadmus.eui.eu//handle/1814/70363

Only in several months time.

Quote:

Merck and BioNTech are further expanding their strategic partnership. Merck, in close collaboration with BioNTech, will significantly accelerate the supply of urgently needed lipids and increase the amount of lipid delivery towards the end of 2021.
Quote:

Lipids are critical to the drug delivery system of mRNA therapies to the body for a vaccine to be effective. Only very few companies in the world are currently able to produce custom lipids in significant quantities and according to the highest quality requirements needed for vaccine production.
100% of Pfizer vaccine production is dependent on the UK.

TheDaddy 22-03-2021 19:30

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36075031)
Only in several months time.



100% of Pfizer vaccine production is dependent on the UK.

And banning imports to the Uk would only put them a week ahead of where they are now, it's all professional blow hardery in the wake of a pretty shambolic effort so far

1andrew1 22-03-2021 19:36

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36075031)
Only in several months time.

100% of Pfizer vaccine production is dependent on the UK.

They're accelerating production hence they're supplying Pfizer currently; ensuring that 100% of Pfizer vaccine is not dependent on the UK.

Quote:

Merck, in close collaboration with BioNTech, will significantly accelerate the supply of urgently needed lipids and increase the amount of lipid delivery towards the end of 2021.

Damien 22-03-2021 22:54

Re: Coronavirus
 
The U.K would have to respond in kind but it's probably best to be cautious before the Government starts sabre-rattling. I think the EU leadership would want nothing better than for Boris Johnson to start making counter-threats and turn this into a Britain vs EU thing for the benefit of their domestic audience.

The U.K should wait and see what they actually do. Then see if it does actually impact us. If they do a tokenistic block of some vaccines from some factories then we should roll our eyes and take the moral high ground leaving the EU looking petulant and ineffective.

If they do start making a notable impact on our vaccine supply and schedules then we have to respond by blocking the export of the ingredients needed. We should also make overtures to European-based pharmaceutical companies to move more production to the U.K on the promise we won't block them from honoring their contracts.

nomadking 23-03-2021 01:15

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075040)
They're accelerating production hence they're supplying Pfizer currently; ensuring that 100% of Pfizer vaccine is not dependent on the UK.

It was recently been confirmed on ITV news that an essential component is only produced in the UK and the US.
Link

Quote:

The East Yorkshire headquartered smart science specialist is supplying an ingredient used in the Pfizer BioNtech Covid-19 vaccine.
The carrier is used to transport the vaccine's active element into the body.
It is produced at sites in the UK and US.
Link

Quote:

The contract with Pfizer runs for five years and awards Croda an initial supply contract for four component excipients - described as the vehicle to transfer the drug - for the first three years of the contract. Demand remains subject to relevant approvals.
4 different lipids are used for the Pfizer vaccine. Others must be used for other products.

Link

Quote:

Lipids
(4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis (ALC-3015)
(2- hexyldecanoate),2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide (ALC-0159)
1,2-distearoyl-snglycero-3-phosphocholine (DPSC)
cholesterol
Link

Quote:

Via its newly acquired subsidiary, Avanti Polar Lipids, Croda has agreed to supply novel excipients used in the manufacture of Pfizer’s mRNA COVID-19 vaccine candidate, for which 90% effectiveness has been claimed in human tests. The five-year deal includes an initial supply contract for four component excipients for the first three years.
"Novel" as in new.

---------- Post added at 01:15 ---------- Previous post was at 00:58 ----------

Quote:

Originally Posted by Damien (Post 36075059)
The U.K would have to respond in kind but it's probably best to be cautious before the Government starts sabre-rattling. I think the EU leadership would want nothing better than for Boris Johnson to start making counter-threats and turn this into a Britain vs EU thing for the benefit of their domestic audience.

The U.K should wait and see what they actually do. Then see if it does actually impact us. If they do a tokenistic block of some vaccines from some factories then we should roll our eyes and take the moral high ground leaving the EU looking petulant and ineffective.

If they do start making a notable impact on our vaccine supply and schedules then we have to respond by blocking the export of the ingredients needed. We should also make overtures to European-based pharmaceutical companies to move more production to the U.K on the promise we won't block them from honoring their contracts.

My point over this, is that the EU goes on about reciprocity, when the UK is supplying 100% of an essential component for the Pfizer vaccine.
In general for a limited production product, it is first ordered, first supplied. The UK has ordered 100m doses of the AZ vaccine. The language used at the time of the pre-order strongly implied that the UK was at the head of the queue for being supplied. That was 3 months before any EU-related deal.

jfman 23-03-2021 08:16

Re: Coronavirus
 
https://www.nih.gov/news-events/news...zeneca-vaccine

Americans kicking up a fuss (again) about Astrazenica paperwork from the clinical trial, potentially using outdated data that could skew efficacy and urging them to "ensure the most accurate, up-to-date efficacy data be made public as quickly as possible".

Be interesting to see if this holds up FDA approval.

1andrew1 23-03-2021 09:06

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36075064)
It was recently been confirmed on ITV news that an essential component is only produced in the UK and the US.
Link

Two months plus ago is a long time in Covid vaccination production. ;) My understanding is that Merck is now a parallel supplier to Croda and ramping up production all the time. However, putting this aside, Pfizer is a US company and its EU plant produces vaccine for all countries outside the US. Yes, even Canada has to get its Pfizer vaccines delivered from Belgium! For this reason, I am sure that Pfizer could tap its US supplier to temporarily fill a gap in UK supply. But I am happy to go on record and predict that Pfizer exports to the UK will not be banned.

Quote:

Originally Posted by nomadking (Post 36075064)
My point over this, is that the EU goes on about reciprocity, when the UK is supplying 100% of an essential component for the Pfizer vaccine.
In general for a limited production product, it is first ordered, first supplied. The UK has ordered 100m doses of the AZ vaccine. The language used at the time of the pre-order strongly implied that the UK was at the head of the queue for being supplied. That was 3 months before any EU-related deal.

Hugh cited the journalist Dave Keating's Tweet yesterday reiterating the EU deal was signed a day before the UK one. We all agree that the UK deal was more tightly worded meaning that no Covid 19 vaccines have been exported from the UK whilst needed in this country. By contrast, the EU has exported some 41 million vaccine doses with a quarter of these going to the UK.

jonbxx 23-03-2021 09:07

Re: Coronavirus
 
Quote:

Originally Posted by heero_yuy (Post 36075005)
The EU would be the big looser here as the Pfizer vaccine is dependent upon supplies of a critical component from the UK as they've bad-mouthed the AZ one.

No. The production of AZ vaccine in the UK would stop dead as the AZ vaccine uses EU sourced ingredients and the production facilities are working 'hand to mouth' with little or no stock built up. On top of that, no Belgium produced Pfizer vaccines for the UK.

Nobody would gain from arbitrarily export controlling raw materials

1andrew1 23-03-2021 09:11

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075069)
https://www.nih.gov/news-events/news...zeneca-vaccine

Americans kicking up a fuss (again) about Astrazenica paperwork from the clinical trial, potentially using outdated data that could skew efficacy and urging them to "ensure the most accurate, up-to-date efficacy data be made public as quickly as possible".

Be interesting to see if this holds up FDA approval.

I guess the US can afford to be perfectionist on this as its vaccination programme is going very well. However, surely any trial data has been superseded by the mass vaccination programmes in place across the World using the AstraZeneca vaccine.

Sephiroth 23-03-2021 09:54

Re: Coronavirus
 
I'd like to put something forward that touches both Covid and Brexit.

1/
Covid doesn't care about the EU or the UK. But Covid has laid low both the EU and UK.

2/
Accordingly, Single Market, Free Movement, Customs Union - they have little relevance to the UK in the Covid context (not speaking for other EU countries).

3/
Covid is something where the population are important stakeholders. The EU, as we know, is not a nation state. To act on behalf of all EU nations where there is no particular competence (as with Covid), the agreement of all 27 members is required such that specific powers are conferred on the EC.

4/
What would have been the case if the UK had been an EU member? Is there a clue when, in the transition year, the UK was invited to join the EU vaccine procurement collective? Presuming that the Oxford Vaccine (and AZ) were all lined up from earlier in the year, I don't think the UK government would have wished to support the EU proposition.

5/
But then if May had remained PM, she would almost certainly have locked on to the EU proposition.

6/
Because the need to survive (a pandemic) trumps everything except public order, the UK people expect the government to pay close attention to its own. The EU is proving itself to be an enemy - a real enemy. I think that Boris' current approach, in so far as we can glean, is the right one. Not to threaten, maintain reticence, hold the line and let the EU keep on being the bad boys.

7/
How right we were to leave the EU. Our lives matter more than the Single Market.





Chris 23-03-2021 09:55

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075070)
Two months plus ago is a long time in Covid vaccination production. ;) My understanding is that Merck is now a parallel supplier to Croda and ramping up production all the time. However, putting this aside, Pfizer is a US company and its EU plant produces vaccine for all countries outside the US. Yes, even Canada has to get its Pfizer vaccines delivered from Belgium! For this reason, I am sure that Pfizer could tap its US supplier to temporarily fill a gap in UK supply. But I am happy to go on record and predict that Pfizer exports to the UK will not be banned.


Hugh cited the journalist Dave Keating's Tweet yesterday reiterating the EU deal was signed a day before the UK one. We all agree that the UK deal was more tightly worded meaning that no Covid 19 vaccines have been exported from the UK whilst needed in this country. By contrast, the EU has exported some 41 million vaccine doses with a quarter of these going to the UK.

Err no, that’s not *quite* what Keating said. The crucial tweet is this one:

Quote:

AstraZeneca signed purchasing agreement with EU one day before its agreement with UK.

AZ CEO told an EP hearing last month that UK priority comes from research funding agreement Oxford signed with UK gov in Jan/Feb 2020, inherited by AZ when it partnered with Oxford in May 2020.
Keating is making a very narrow technical point when he says the EU signed a purchasing agreement the day before the UK did. The fact is there was no immediate hurry for the UK to conclude precise purchase terms because priority of supply was already established, thanks to the UK government’s foresight in:

1. Funding vaccine research well before covid became a problem in the UK
2. Insisting that the eventual product must be manufactured in the UK so that supply to the UK could be assured
3. Ensuring terms relating to priority of supply were written in from the outset, and
4. Ensuring those terms were rolled on to AsraZeneca when it received the contract to manufacture.

UK priority does not arise from a later, but better, agreement than the one the EU signed. It arises from funding, negotiations and a priority of supply agreement between the UK and Oxford, and latterly AZ, that was all in place much, much earlier.

In this context the UK’s later conclusion of purchase terms is irrelevant - all the important supply terms were already in place.

jfman 23-03-2021 10:06

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075072)
I guess the US can afford to be perfectionist on this as its vaccination programme is going very well. However, surely any trial data has been superseded by the mass vaccination programmes in place across the World using the AstraZeneca vaccine.

I guess the issue is that while nobody is disputing it's safe and effective it's the absence of clear data from clinically controlled trials (and against variants) that makes it difficult to quantify how much and where to deploy which is why there is the call for transparency.

It might also make Governments rethink incentives to push people to get vaccinated if the herd immunity threshold is only going to be achieved with near 100% uptake.

nomadking 23-03-2021 10:24

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075070)
Two months plus ago is a long time in Covid vaccination production. ;) My understanding is that Merck is now a parallel supplier to Croda and ramping up production all the time. However, putting this aside, Pfizer is a US company and its EU plant produces vaccine for all countries outside the US. Yes, even Canada has to get its Pfizer vaccines delivered from Belgium! For this reason, I am sure that Pfizer could tap its US supplier to temporarily fill a gap in UK supply. But I am happy to go on record and predict that Pfizer exports to the UK will not be banned.


Hugh cited the journalist Dave Keating's Tweet yesterday reiterating the EU deal was signed a day before the UK one. We all agree that the UK deal was more tightly worded meaning that no Covid 19 vaccines have been exported from the UK whilst needed in this country. By contrast, the EU has exported some 41 million vaccine doses with a quarter of these going to the UK.

June 2020
Quote:

AstraZeneca has reached an agreement with Europe’s Inclusive Vaccines Alliance (IVA), spearheaded by Germany, France, Italy and the Netherlands, to supply up to 400 million doses of the University of Oxford’s COVID-19 vaccine, with deliveries starting by the end of 2020.
...
The Company has recently completed similar agreements with the UK, US, the Coalition for Epidemic Preparedness Innovations and Gavi the Vaccine Alliance for 700 million doses, and it agreed a licence with the Serum Institute of India for the supply of an additional one billion doses, principally for low- and middle-income countries. Total manufacturing capacity currently stands at two billion doses.
Link
Quote:

The bloc signed a deal in August for 300 million doses, with an option for 100 million more.
May 2020
Quote:

Meanwhile, Oxford University signed a global licensing agreement with AstraZeneca for the manufacturing and commercialisation of their vaccine candidate. If the vaccine is successful, AstraZeneca will produce up to 30 million doses by September for people in the UK. The agreement is for the pharmaceutical company to deliver a total of 100 million doses.
Business Secretary Alok Sharma said: “Our scientists are at the forefront of vaccine development. This deal with AstraZeneca means that if the Oxford University vaccine works, people in the UK will get the first access to it, helping to protect thousands of lives.
Link
Quote:

And some components used in making the vaccine may be made at yet another location. For example, a UK company called Croda is supplying a component to Pfizer to make its vaccine.
The lipid components - fat molecules used to encase the virus's fragile genetic material and transport it into the body - are in relatively short supply, according to science data company Airfinity.
Quote:

The EU has ordered 400 million doses of the Oxford-AstraZeneca vaccine.
The company says supplies are coming mainly from the US and a site in Seneffe in Belgium. AstraZeneca is working with suppliers in 15 countries to make the vaccine.
A site in Leiden in the Netherlands is also producing some vaccine, although the pharmaceutical company said it was not significant.
AstraZeneca confirmed that the UK has not received any vaccines or components from the EU - apart from one "tiny" batch from the Leiden plant.
Link
Quote:

The VTF’s strategy was to move quickly to strike deals with the most promising vaccine candidates. This approach, together with the efforts made by suppliers, has offered several advantages to the UK and ultimately enabled the rapid availability of COVID-19 vaccines in the UK. The UK was the first country in the world to secure access to the Pfizer/BioNTech vaccine and to start deploying it as an authorised vaccine (under Regulation 174). The UK was also the first country to procure, authorise (under Regulation 174) and commence deployment of the Oxford/AstraZeneca vaccine.
The AZ vaccine used technology funded by the UK way back in 2016.
Quote:

The need to invest in vaccines and develop them quickly in a pandemic was recognised by government well ahead of COVID-19. The UK government took concerted and coordinated action to invest £120m between 2016 and 2021 for the development of new vaccines, in line with the expert advice provided by the UKVN, made up of leading experts from academia, industry and policy. The UKVN funded Oxford University £1.87m to develop a MERS (another coronavirus) vaccine. This MERS vaccine technology was rapidly repurposed to develop a COVID-19 vaccine using initial funding from an NIHR and UKRI research call launched in February.
In April the government announced £20m of further funding so that the Oxford clinical trials could commence immediately.
The UK was funding development of the AZ vaccine more than a year ago.

Mr K 23-03-2021 10:34

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36075082)
June 2020
Link
May 2020
Link
Link
The AZ vaccine used technology funded by the UK way back in 2016.
The UK was funding development of the AZ vaccine more than a year ago.

Do get out old chap, its a lovely day, spring flowers, birds singing etc. ;)

jonbxx 23-03-2021 11:24

Re: Coronavirus
 
Quote:

Originally Posted by Sephiroth (Post 36075075)
I'd like to put something forward that touches both Covid and Brexit.

1/
Covid doesn't care about the EU or the UK. But Covid has laid low both the EU and UK.

2/
Accordingly, Single Market, Free Movement, Customs Union - they have little relevance to the UK in the Covid context (not speaking for other EU countries).

3/
Covid is something where the population are important stakeholders. The EU, as we know, is not a nation state. To act on behalf of all EU nations where there is no particular competence (as with Covid), the agreement of all 27 members is required such that specific powers are conferred on the EC.

4/
What would have been the case if the UK had been an EU member? Is there a clue when, in the transition year, the UK was invited to join the EU vaccine procurement collective? Presuming that the Oxford Vaccine (and AZ) were all lined up from earlier in the year, I don't think the UK government would have wished to support the EU proposition.

5/
But then if May had remained PM, she would almost certainly have locked on to the EU proposition.

6/
Because the need to survive (a pandemic) trumps everything except public order, the UK people expect the government to pay close attention to its own. The EU is proving itself to be an enemy - a real enemy. I think that Boris' current approach, in so far as we can glean, is the right one. Not to threaten, maintain reticence, hold the line and let the EU keep on being the bad boys.

7/
How right we were to leave the EU. Our lives matter more than the Single Market.





But let's not forget it is in the UKs interest for EU states to get over the pandemic and open up for business. Every time trade figures come out, some people go 'aha, Brexit!' and others go 'aha, COVID!' If the 'aha COVID!' people are right, then the restoring of normal economic activity in the EU can only be a good thing for the UKs trade figures.

nomadking 23-03-2021 11:39

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075092)
But let's not forget it is in the UKs interest for EU states to get over the pandemic and open up for business. Every time trade figures come out, some people go 'aha, Brexit!' and others go 'aha, COVID!' If the 'aha COVID!' people are right, then the restoring of normal economic activity in the EU can only be a good thing for the UKs trade figures.

Little point letting people from the EU into this country, if we still have a large number of people in this country yet unvaccinated.
As things stand, the EU is so large and behind in vaccinating people, that whatever is done it will be a long time before it would be safe for people from the EU to come here.
If pretty much the whole of the UK has been vaccinated, then there would be a lot less risk in allowing people to come here, and for people from the UK to go elsewhere(eg Spain). If X% of the UK were not yet vaccinated, that X% would be at risk from EU visitors, or to the EU if they went there.


One EU leader gets it.
Quote:

Irish Taoiseach Micheal Martin warned that a ban would be 'a very retrograde step' which would prove counter-productive.
Mr Martin, who could face the prospect of the EU imposing a hard border with Northern Ireland to prevent vaccines entering the UK, said he had made it 'very clear' to fellow leaders he was opposed.
'They're not EU vaccines,' he said. 'These are vaccines paid for by other countries that are manufactured in Europe.'


Sephiroth 23-03-2021 11:51

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075092)
But let's not forget it is in the UKs interest for EU states to get over the pandemic and open up for business. Every time trade figures come out, some people go 'aha, Brexit!' and others go 'aha, COVID!' If the 'aha COVID!' people are right, then the restoring of normal economic activity in the EU can only be a good thing for the UKs trade figures.

I may be wrong, Jon, but the EU is out to get us. They are pursuing the UK for various alleged past infringements and, at least in the short term, there is very little there for us.

If they go so far as to ban vaccine exports, then the UK is in a life threatening position. All trust and conciliation would be lost and we might as well abandon the treaty because of the EU’s act of aggression.

We can build trade elsewhere. The EC is a nasty, vindictive executive and if the 27 nations back what the EC proposes then there is little point in pretending that they are worthwhile partners.



1andrew1 23-03-2021 11:53

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075092)
But let's not forget it is in the UKs interest for EU states to get over the pandemic and open up for business. Every time trade figures come out, some people go 'aha, Brexit!' and others go 'aha, COVID!' If the 'aha COVID!' people are right, then the restoring of normal economic activity in the EU can only be a good thing for the UKs trade figures.

Surely it's in the UK's interests for every country to be vaccinated? It stops the virus spreading as much and therefore reduces its opportunity to mutate with its consequences on the need to limit overseas travel and the need for new vaccines.

Sephiroth 23-03-2021 11:57

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075098)
Surely it's in the UK's interests for every country to be vaccinated? It stops the virus spreading as much and therefore reduces its opportunity to mutate with its consequences on the need to limit overseas travel and the need for new vaccines.

The EC is acting as in EU first which contrasts with your desire. Of course you are right, provided there is enough to go round.

I pay my taxes for the UK government to protect me, not France, etc. I expect the government to act accordingly including red-listing EU countries immediately.

Carth 23-03-2021 12:10

Re: Coronavirus
 
May I butt in with a couple of questions?

Has it yet been proven that the vaccine prevents you from catching Covid-19?

If it doesn't, can you catch it and spread it to others?

If you've had the first and second jab, then go out and mingle with people who have tested positive, would you still be 'told' by track & trace to isolate for a week?

It seems (to a fikko like me) that there are more grey areas than a library (remember those? ) full of pensioners :D

Mick 23-03-2021 12:10

Re: Coronavirus
 
Quote:

Originally Posted by Mr K (Post 36075085)
Do get out old chap, its a lovely day, spring flowers, birds singing etc. ;)

Good advice.

For him.

Few days leave from this topic granted. [Amended to at least 2 days]

Cable Forum Topic holidays. ATOL Protected.

Maggy 23-03-2021 12:10

Re: Coronavirus
 
I am not taking part in any silences or clapping. I'm not patting this government on it's back particularly for the shabby way they are treating the nurses when if they had locked down at least a month earlier more lives might have been saved. Closing the borders was the FIRST thing they should have done.The only thing they got right was supporting finding a vaccine which was the very least thing they have done. The ONLY people who deserve any accolades are the key workers which is better dealt with by paying them a decent wage and hopefully a bonus.

jonbxx 23-03-2021 12:16

Re: Coronavirus
 
Quote:

Originally Posted by Sephiroth (Post 36075099)
The EC is acting as in EU first which contrasts with your desire. Of course you are right, provided there is enough to go round.

I pay my taxes for the UK government to protect me, not France, etc. I expect the government to act accordingly including red-listing EU countries immediately.

If it's the expectation that the UK looks after its' own, then surely other countries or blocs of countries looking after their own is reasonable too?

The US has been doing this since day one of course with a ban on vaccine exports.

Chris 23-03-2021 12:34

Re: Coronavirus
 
Quote:

Originally Posted by Mick (Post 36075102)
Good advice.

For him.

One weeks leave from this topic granted.

Cable Forum Topic holidays. ATOL Protected.

Members please note that Cable Forum Topic Holidays™ must be taken within the UK, in accordance with coronavirus restrictions. :D

daveeb 23-03-2021 14:14

Re: Coronavirus
 
Quote:

Originally Posted by Maggy (Post 36075103)
I am not taking part in any silences or clapping. I'm not patting this government on it's back particularly for the shabby way they are treating the nurses when if they had locked down at least a month earlier more lives might have been saved. Closing the borders was the FIRST thing they should have done.The only thing they got right was supporting finding a vaccine which was the very least thing they have done. The ONLY people who deserve any accolades are the key workers which is better dealt with by paying them a decent wage and hopefully a bonus.

:clap: I'm sure a handclap on the steps of number 10 more than makes up for their miserly pay award.

jonbxx 23-03-2021 15:09

Re: Coronavirus
 
Quote:

Originally Posted by Carth (Post 36075101)
May I butt in with a couple of questions?

Has it yet been proven that the vaccine prevents you from catching Covid-19?

If it doesn't, can you catch it and spread it to others?

If you've had the first and second jab, then go out and mingle with people who have tested positive, would you still be 'told' by track & trace to isolate for a week?

It seems (to a fikko like me) that there are more grey areas than a library (remember those? ) full of pensioners :D

Very good questions and it seems that the simple answer is we don't know for sure if any vaccine will stop infections and stop you spreading the bug. What we do know is that the vaccination makes the likelihood of you getting really sick and even dying much less. If everyone gets vaccinated, COVID at worst becomes the sniffles.

Here's a really good article on this here - https://www.nature.com/articles/d41586-021-00450-z

The best way to answer your questions is to do a challenge test where some hardy souls/heroes/people desperate for cash/complete mugs get deliberately infected with SARS-COV2. A trial is about to be started here in the UK - https://www.gov.uk/government/news/w...oval-in-the-uk

1andrew1 23-03-2021 15:36

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075126)
The best way to answer your questions is to do a challenge test where some hardy souls/heroes/people desperate for cash/complete mugs get deliberately infected with SARS-COV2. A trial is about to be started here in the UK - https://www.gov.uk/government/news/w...oval-in-the-uk

That looks like the basis of a great reality TV series!

With ITV missing out on Love Island this year due to the pandemic, this would seem like an ideal prime time schedule-filler for them. :D

Carth 23-03-2021 15:42

Re: Coronavirus
 
Celebrity Covid, finally we get a reality TV program worth watching :tu:

Heck, I may even be inclined to join the public telephone vote as to which one gets the placebo :D

pip08456 23-03-2021 16:42

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075126)
Very good questions and it seems that the simple answer is we don't know for sure if any vaccine will stop infections and stop you spreading the bug. What we do know is that the vaccination makes the likelihood of you getting really sick and even dying much less. If everyone gets vaccinated, COVID at worst becomes the sniffles.

Here's a really good article on this here - https://www.nature.com/articles/d41586-021-00450-z

The best way to answer your questions is to do a challenge test where some hardy souls/heroes/people desperate for cash/complete mugs get deliberately infected with SARS-COV2. A trial is about to be started here in the UK - https://www.gov.uk/government/news/w...oval-in-the-uk

Is there any vaccine in existance that actually stops anyone being infected? Surely all a vaccine does is prepare the immune system to recognise and fight an infection quicker than the immune system starting from scratch.

jonbxx 23-03-2021 16:57

Re: Coronavirus
 
Quote:

Originally Posted by pip08456 (Post 36075135)
Is there any vaccine in existance that actually stops anyone being infected? Surely all a vaccine does is prepare the immune system to recognise and fight an infection quicker than the immune system starting from scratch.

Not really, no as whatever infectious agent has to be in you for your immune system to act on it so you are to some extent 'infected'. A race is then on between the infectious agent multiplying and the immune system stamping it down.

Vaccines vary a lot in how much they stimulate the immune system. It does depend on how 'foreign' the disease is. A 'good' disease is one that can escape the immune system by either disguising the parts which the immune system recognises - see HIV or changing rapidly - see influenza.

You can help a bit by adding other agents which also stimulate the immune system. These are called adjuvants. When you hear about aluminium in vaccines, that is aluminium hydroxide powder which makes your immune system go crazy. It can also help by administering the vaccine through the same route as the disease (see Flumist flu vaccine and Polio vaccines) but that is really hard to do so they mostly get injected.

jfman 23-03-2021 17:54

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075126)
Very good questions and it seems that the simple answer is we don't know for sure if any vaccine will stop infections and stop you spreading the bug. What we do know is that the vaccination makes the likelihood of you getting really sick and even dying much less. If everyone gets vaccinated, COVID at worst becomes the sniffles.

Here's a really good article on this here - https://www.nature.com/articles/d41586-021-00450-z

The best way to answer your questions is to do a challenge test where some hardy souls/heroes/people desperate for cash/complete mugs get deliberately infected with SARS-COV2. A trial is about to be started here in the UK - https://www.gov.uk/government/news/w...oval-in-the-uk

Is the Pfizer data from Israel not supporting that it reduces transmission?

Hugh 23-03-2021 18:38

Re: Coronavirus
 
https://www.washingtonpost.com/world...9ac_story.html

Quote:

AstraZeneca used ‘outdated and potentially misleading data’ that overstated the effectiveness of its vaccine, independent panel says

AstraZeneca said it would “immediately engage” with an independent data and safety monitoring board to discuss the most up-to-date efficacy data on its coronavirus vaccine.

In an extraordinary turn of events, an independent panel that safeguards the integrity of clinical trials wrote to AstraZeneca and U.S. government officials late Monday expressing concern and disappointment that the drugmaker presented “outdated and potentially misleading” data on its coronavirus vaccine making the shots appear more effective than shown by fuller data.

The letter, from 11 leading statisticians, infectious-disease physicians and ethics experts appointed by the National Institutes of Health to review the trial data for all the major coronavirus vaccines supported by the federal government, says the company’s decision puts the vaccine in the most favorable light — a grave scientific misstep that could erode trust in the vaccine...

...“The DSMB is concerned that AstraZeneca chose to use data that was already outdated and potentially misleading in their press release,” the letter states. “The point that is clear to the board is that the [vaccine efficacy number] . . . they chose to release was the most favorable for the study as opposed to the most recent and most complete. Decisions like this are what erode public trust in the scientific process.”

The letter goes on to explain that while the company announced its vaccine was 79 percent effective on Monday, the panel had been meeting with the company through February and March and had seen data showing the vaccine may be 69 to 74 percent effective, and had “strongly recommended” that information should be included in the news release.

Federal officials were taken aback by the letter from the board. One said the AstraZeneca results were the equivalent of “telling your mother you got an A in a course, when you got an A in the first quiz but a C in the overall course.” Another said the disclosure by the board would inevitably hurt the company’s credibility with U.S. regulators.

Sephiroth 23-03-2021 18:39

Re: Coronavirus
 
Quote:

Originally Posted by jonbxx (Post 36075104)
If it's the expectation that the UK looks after its' own, then surely other countries or blocs of countries looking after their own is reasonable too?

The US has been doing this since day one of course with a ban on vaccine exports.

Indeed. But the EU's approach to this opportunity has been entirely belligerent and hostile. And in public at that. That kind of behaviour needs to be rebuffed, imo.

Had the EU come to the UK and quietly asked if we could help them out, then I would have expected a an accommodation with 'our European friends".

However, Macron and Merkel publicly trashed AZ vaccine to the extent that there is major public resistance to that vaccine.

The above said, I'm sure that the UK government will offer something to the EU, which they don't deserve.


Carth 23-03-2021 18:52

Re: Coronavirus
 
I've got a snooker cue, some golf clubs, and an unused season ticket they can have, no use to me :(

Sephiroth 23-03-2021 20:01

Re: Coronavirus
 
Quote:

Originally Posted by Carth (Post 36075146)
I've got a snooker cue, some golf clubs, and an unused season ticket they can have, no use to me :(

You're too kind, I'm sure.

Hugh 23-03-2021 20:42

Re: Coronavirus
 
https://www.aol.co.uk/news/stanley-j...UWUTQSLSisQpL5

Quote:

The new regulations for the coming months, covering the Prime Minister’s “road map” out of lockdown for England, include a ban on leaving the country without a valid reason.

One of the exemptions allows travel to visit properties, estate agents, sales offices or show homes overseas if a person is seeking to buy or sell a foreign home.

The legislation also gives an exemption for “preparing a residential property to move in” or “to visit a residential property to undertake any activities required for the rental or sale of that property”.

1andrew1 23-03-2021 22:07

Re: Coronavirus
 
Quote:

Originally Posted by Hugh (Post 36075150)

"Nice one, son."
S.J., Winsford, Somerset
;)

GrimUpNorth 23-03-2021 22:19

Re: Coronavirus
 
Quote:

Originally Posted by Hugh (Post 36075150)

Wonder if glancing in the estate agents window on your way to the beach counts?

OLD BOY 24-03-2021 07:38

Re: Coronavirus
 
Quote:

Originally Posted by Maggy (Post 36075103)
I am not taking part in any silences or clapping. I'm not patting this government on it's back particularly for the shabby way they are treating the nurses when if they had locked down at least a month earlier more lives might have been saved. Closing the borders was the FIRST thing they should have done.The only thing they got right was supporting finding a vaccine which was the very least thing they have done. The ONLY people who deserve any accolades are the key workers which is better dealt with by paying them a decent wage and hopefully a bonus.

Didn't Whitty advise AGAINST an early lockdown?

If that was the scientific advice, then you cannot correctly blame the government for getting it wrong. Whitty said:

"...if we go too early, people will understandably get fatigued and it will be difficult to sustain this over time".

Wasn't it the World Health Organisation that was advising against closing the borders because "evidence shows that restricting the movement of people and goods during public health emergencies is ineffective in most situations and may divert resources from other interventions"?

The government had a lot to weigh up in those early days and was receiving conflicting advice due to the many unknowns, not to mention fears for the economy. Blaming the government for anything that went wrong is a cheap shot.

jfman 24-03-2021 07:51

Re: Coronavirus
 
Quote:

Originally Posted by OLD BOY (Post 36075157)
Didn't Whitty advise AGAINST an early lockdown?

If that was the scientific advice, then you cannot correctly blame the government for getting it wrong. Whitty said:

"...if we go too early, people will understandably get fatigued and it will be difficult to sustain this over time".

Wasn't it the World Health Organisation that was advising against closing the borders because "evidence shows that restricting the movement of people and goods during public health emergencies is ineffective in most situations and may divert resources from other interventions"?

The government had a lot to weigh up in those early days and was receiving conflicting advice due to the many unknowns, not to mention fears for the economy. Blaming the government for anything that went wrong is a cheap shot.

Absolute nonsense Old Boy, anything to deflect from the idea the Government made mistakes. One year on, same old OB.

What Whitty’s public statements on early/later lockdown were made are irrelevant. He’s not going to go out and publicly say something against Government policy. By that point the decisions have been made and lines agreed, unless he fancies resigning.

Pointing to discredited WHO advice is a red herring and by mid-March many other countries were going against it.

Sephiroth 24-03-2021 08:47

Re: Coronavirus
 
Quote:

Originally Posted by Sephiroth (Post 36075145)
Indeed. But the EU's approach to this opportunity has been entirely belligerent and hostile. And in public at that. That kind of behaviour needs to be rebuffed, imo.

Had the EU come to the UK and quietly asked if we could help them out, then I would have expected a an accommodation with 'our European friends".

However, Macron and Merkel publicly trashed AZ vaccine to the extent that there is major public resistance to that vaccine.

The above said, I'm sure that the UK government will offer something to the EU, which they don't deserve.


In relation to the above, an interesting article appeared in yesterday's Torygraph, written by Charles Moore. The thrust of the article is:

1. We have enough AZ vaccine to meet our 2nd dose needs;

2. We are vulnerable to EU action on 2nd dose Pfizer needs;

3. The UK should bail the EU out as there will be returns for us.

Quote:

The European Union wants to grab supplies of the AstraZeneca vaccine, including those from the Halix factory in Leyden, Holland. This is particularly rich, since Halix’s production success owes much to a team sent over at Christmas by Kate Bingham’s Vaccine Task Force. The company was lagging behind the production of the same vaccine in Oxford. It needed our help to achieve the necessary scale by installing 1,000-litre bio-reactors.

Britain was able to step in because it was about five months ahead of EU plans for vaccine deployment. Its assistance was good both for this country and for the EU. This is part of the context in which the EU, so desperate to avoid blame for its own sloth and maladministration, now threatens to break contracts and deprive Britain of vaccines coming out of Halix and other continental suppliers.

Almost everyone here agrees that the EU’s behaviour is disgraceful, and that Britain is within its rights. Even inside the EU, public opinion is dismayed. How best, though, to react?

I would tentatively suggest that this country is in a position to be super-nice. We are way ahead of Europe, and we already have enough AstraZeneca vaccine to administer the second doses we need. In the slightly longer term, everything seems to be on track for our plentiful supply of Novovax (60 million doses) and Valdema. So long as Europe sticks by its promise to deliver the second doses of Pfizer-BioNTech our vulnerable need, we should consider helping.

Obviously, it is our absolute duty to vaccinate all vulnerable British residents first; but if that duty is discharged, is it essential that we rush forward at the same pace to vaccinate everyone else? We already have enough to cover “priority groupings” 1 to 9. The drive to get every 25-year-old vaccinated by the summer is good propaganda but will have little impact on death and infection rates if our vulnerable are already safe.

There is a moral case for helping the EU. Britain has the capacity to help rescue millions of elderly on the Continent and thus prevent thousands of deaths by offering some of its own vaccines.

There is an economic case, too. Even when we become well protected here – a day which is not far off – we shall not be able to recover economic normality if our neighbours continue to be locked down. We could free Europe from that curse. If it can be done, it will be the best lead we have given to Europe since 1945.

jfman 24-03-2021 08:56

Re: Coronavirus
 
Millions of elderly? Even Professor Pantsdown wasn’t that much of a doom-monger.

Sephiroth 24-03-2021 09:09

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075163)
Millions of elderly? Even Professor Pantsdown wasn’t that much of a doom-monger.

You're weird!

jonbxx 24-03-2021 09:11

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075139)
Is the Pfizer data from Israel not supporting that it reduces transmission?

The simple answer is 'sort of/maybe' at this point. What is known is that the Pfizer vaccine reduces symptomatic and, importantly, asymptomatic infections. There also seems to be some good evidence coming out that the virus is cleared more quickly in infected vaccinated people.

If you think about how you get infected with SARS-COV2, you need to get close enough to someone who is shedding virus and breathe in virus particles in a high enough dose. Symptomatic people are a huge issue and they will coughing away and shedding a lot more virus in to the air so not only is virus coming out, it's getting forced out at speed (evolution is great!) BUT, at this stage, if you are symptomatic, in all likelihood you are going to think 'Uh oh, COVID' and isolate and get tested. Also, masks will help catch the droplets being sprayed out by a symptomatic person.

Logically, an asymptomatic person will be less infectious as they aren't coughing but the evidence is weak right now on how much less infectious they are. Kids are more likely to be asymptomatic, hence the in school testing going on right now (I have a big stack of test kit boxes on my dining room table right now for home testing of the kids) Te downside of asymptomatic people is that they are not isolating - they are merrily going about their way shedding virus. What we need to know is what the 'R' value is for an asymptomatic person and that isn't clear right now.

So, vaccines seem to reduce the numbers of people actively spreading SARS-COV2 by coughing and the numbers of people unwittingly spreading infection and the infective period seems less so, in all likelihood, vaccines will reduce transmission as there are less people spreading the virus. What is less clear is how infectious you are if you are vaccinated but infected. This is one of the reasons why the Government is asking vaccinated people to not go crazy (there are other behavioural reasons too of course)

Hom3r 24-03-2021 10:29

Re: Coronavirus
 
I had my Oxford AstraZenecia jab on Monday morning.


I woke up on Tuesday feeling like I had a cold, and just rundown, my Brother in-law had his just before me, but he felt like crap.


This morning we are both getting back to normal, and one step closer to family hugs.

joglynne 24-03-2021 11:51

Re: Coronavirus
 
Quote:

Originally Posted by Hom3r (Post 36075167)
I had my Oxford AstraZenecia jab on Monday morning.


I woke up on Tuesday feeling like I had a cold, and just rundown, my Brother in-law had his just before me, but he felt like crap.


This morning we are both getting back to normal, and one step closer to family hugs.

I had my 2nd Pfizer Vaccination 8am yesterday morning. Arm painful overnight and still tender this morning but other than that I feel fine.

At last I can add the 2nd jab to my Covid Symptons Study app. Worth having a look at the results of the study if you haven't come across it before.

https://covid.joinzoe.com/

nomadking 24-03-2021 14:35

Re: Coronavirus
 
EU is getting a bit paranoid.
Link

Quote:

Meanwhile, 29 million AZ doses have been inspected in a raid in Italy.
The Italian government said the health squad of the military police had gone to "verify" batches at a plant in Anagni, near Rome, last weekend after a request by the European Commission.


The plant has a contract with AstraZeneca to fill the vials with the vaccine and label them - known as "fill and finish". The plant will do the same for the Johnson & Johnson vaccine, which is also approved for use in the EU.


La Stampa newspaper reported that the UK was a possible destination for some of the doses but a UK government official said it was not expecting such a delivery. The Italian government said "the batches that were inspected were all aimed for Belgium".




OLD BOY 24-03-2021 15:28

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075159)
Absolute nonsense Old Boy, anything to deflect from the idea the Government made mistakes. One year on, same old OB.

What Whitty’s public statements on early/later lockdown were made are irrelevant. He’s not going to go out and publicly say something against Government policy. By that point the decisions have been made and lines agreed, unless he fancies resigning.

Pointing to discredited WHO advice is a red herring and by mid-March many other countries were going against it.

Same old argumentative jfman.

It is a fact that Whitty said that, and if you remember, the government has always said that they were following scientific advice.

The WHO advice may have been discredited subsequently (if you say so) but the fact is, that’s the medical advice that was there.

Government decisions? Yes. Medical advice at the time? Yes.

What other countries were doing, frankly, is irrelevant.

papa smurf 24-03-2021 15:30

Re: Coronavirus
 
Quote:

Originally Posted by nomadking (Post 36075182)
EU is getting a bit paranoid.
Link

Better keep an eye on the Belgian border to see if the krauts are amassing troops /panzer divisions:)

jfman 24-03-2021 15:41

Re: Coronavirus
 
Quote:

Originally Posted by OLD BOY (Post 36075184)
Same old argumentative jfman.

It is a fact that Whitty said that, and if you remember, the government has always said that they were following scientific advice.

The WHO advice may have been discredited subsequently (if you say so) but the fact is, that’s the medical advice that was there.

Government decisions? Yes. Medical advice at the time? Yes.

What other countries were doing, frankly, is irrelevant.

I’m not being argumentative I’m simply pointing out you are contributing palpable nonsense. Did the Government ignore SAGE advice to lockdown around 11th March? Yes. Did they ignore similar in September? Yes.

You’re quoting one man on Government payroll and giving that greater weight than the scientific advisory groups the Government appointed to give advice. Ministers make decisions based on (or against) that advice at their own discretion.

Hugh 24-03-2021 16:06

Re: Coronavirus
 
Quote:

Originally Posted by papa smurf (Post 36075185)
Better keep an eye on the Belgian border to see if the krauts are amassing troops /panzer divisions:)

Commando comics called - could they have their out-dated language back, please? :D

Chris 24-03-2021 16:07

Re: Coronavirus
 
Quote:

Originally Posted by Hugh (Post 36075189)
Commando comics called - could they have their out-dated language back, please? :D

Nein, but you can have this pineapple, Fritz.

Hugh 24-03-2021 16:30

Re: Coronavirus
 
Quote:

Originally Posted by Chris (Post 36075190)
Nein, but you can have this pineapple, Fritz.

Amusingly, they are now printed by GGP Media in Germany - Karl-Marx-Straße in Pößneck... :D

papa smurf 24-03-2021 16:31

Re: Coronavirus
 
Quote:

Originally Posted by Hugh (Post 36075189)
Commando comics called - could they have their out-dated language back, please? :D

Next it'll be cabbage crates over the briny.

Hugh 24-03-2021 16:35

Re: Coronavirus
 
Wing Commander: I want you to lay down your life, Papa. We need a futile gesture at this stage. It will raise the whole tone of the war. Get up in a crate, Papa, pop over to Bremen, take a shufti, don't come back. Goodbye Papa. God, I wish I was going too.

Papa: Goodbye sir - or is it “au revoir"?

Wing Commander: No, Papa...

(thank you, Peter Cook)

Chris 24-03-2021 18:12

Re: Coronavirus
 
This looks like a thoroughly meaningless statement.

https://www.bbc.co.uk/news/live/uk-5...ost_type=share

Quote:

The UK and EU have said they are working on creating a "win-win" situation and to expand vaccine supply for all citizens, as the row involving demand for the Oxford/AstraZeneca jab continues.

The UK government and European Commission have just released a joint statement.

“We are all facing the same pandemic and the third wave makes co-operation between the EU and UK even more important," it reads.

"We have been discussing what more we can do to ensure a reciprocally beneficial relationship between the UK and EU on Covid-19.
But I thought the EU’s complaint was the commercial terms of a contract they signed with a private company? And that the new export control measures were not aimed at any particular country (despite the terms of control being a suspiciously accurate description of the UK’s status re vaccines)? Why then are they now seeking a “reciprocally beneficial relationship” with HMG? Are they finally going to admit that they royally fecked up their whole vaccine plan and they need our help to fix it?

papa smurf 24-03-2021 18:22

Re: Coronavirus
 
It didn't take our "EU friends" long to revert back to being the old enemy :(

OLD BOY 24-03-2021 18:23

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075188)
I’m not being argumentative I’m simply pointing out you are contributing palpable nonsense. Did the Government ignore SAGE advice to lockdown around 11th March? Yes. Did they ignore similar in September? Yes.

You’re quoting one man on Government payroll and giving that greater weight than the scientific advisory groups the Government appointed to give advice. Ministers make decisions based on (or against) that advice at their own discretion.

The medical establishment has been looking in different directions on this, and Whitty advised as he advised. His arguments were the ones taken into account.

SAGE may have thought differently at another point in time, but there were many other factors that had to be taken into account, and not all of them were medical issues. You are over-simplifying this to an extraordinary level to try and win your unfounded argument. But to try to paint a picture that the government was not listening to medical and other professional advice is just fanciful.

Chris 24-03-2021 18:32

Re: Coronavirus
 
Quote:

Originally Posted by papa smurf (Post 36075198)
It didn't take our "EU friends" long to revert back to being the old enemy :(

Hopefully Boris has been busy on the phone pointing out that the EU risks serious long-term difficulties in its vaccine supplies for the short term domestic PR gain of blocking movement of vaccines or components from the EU to the UK. We are cooking a lot of vaccine here, we have a lot more influence over the other major source of the AZ vaccine (India) than the EU does, and we’re not just making AZ here in the UK. Around a third of Valneva’s manufacturing capacity is now in Scotland. A rather important component of the Pfizer vaccine is made in East Yorkshire. If the EU were to try to start a vaccine war it would be a self defeating move.

jfman 24-03-2021 18:35

Re: Coronavirus
 
Quote:

Originally Posted by OLD BOY (Post 36075199)
The medical establishment has been looking in different directions on this, and Whitty advised as he advised. His arguments were the ones taken into account.

SAGE may have thought differently at another point in time, but there were many other factors that had to be taken into account, and not all of them were medical issues. You are over-simplifying this to an extraordinary level to try and win your unfounded argument. But to try to paint a picture that the government was not listening to medical and other professional advice is just fanciful.

Rubbish Old Boy. The Government ignored advice on lockdowns 1 and 2. These are matters of public record.

What is fanciful is the idea that the Chief Medical Officer, or Chief Scientific Adviser, could or would go public and make statements that actively contradict Government policy as agreed by Ministers.

You are greatly over-complicating the situation to allow yourself to claim that the Government have been blameless at all times. Over lockdowns, PPE, billions for Dido Harding’s non-functioning contract tracing... always someone else to blame.

1andrew1 24-03-2021 19:18

Re: Coronavirus
 
Quote:

Originally Posted by Chris (Post 36075200)
,...we have a lot more influence over the other major source of the AZ vaccine (India) than the EU does...

Neither of us has much influence over it at the moment!
Quote:

India 'bans export of AstraZeneca vaccine' as country tackles major Covid outbreak
India has banned vaccine exports from the Serum Institute of India after a spike in infections, with sources claiming no jabs will leave the country until the situation stabilises.
https://www.mirror.co.uk/news/world-...eneca-23789417

---------- Post added at 19:18 ---------- Previous post was at 19:07 ----------

Quote:

Originally Posted by jfman (Post 36075203)
Rubbish Old Boy. The Government ignored advice on lockdowns 1 and 2. These are matters of public record.

What is fanciful is the idea that the Chief Medical Officer, or Chief Scientific Adviser, could or would go public and make statements that actively contradict Government policy as agreed by Ministers.

You are greatly over-complicating the situation to allow yourself to claim that the Government have been blameless at all times. Over lockdowns, PPE, billions for Dido Harding’s non-functioning contract tracing... always someone else to blame.

Well handled
  • Press conferences with medical experts
  • Vaccination procurement
  • Vaccination pre-procurement and onshoring
  • Vaccination roll-out

Badly handled
  • Test and trace
  • Late lockdowns
  • Christmas situation
  • PPE procurement
  • Discharge of infected patients into nursing homes
  • NHS pay rise
  • Dominic Cummings fiasco
  • Not limiting inbound travel from overseas until fairly recently

I think Boris's performance is improving whilst some other leaders are worsening, eg Angela Merkel and her last-minute Easter extension which the country revolted against.

OLD BOY 24-03-2021 19:23

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075203)
Rubbish Old Boy. The Government ignored advice on lockdowns 1 and 2. These are matters of public record.

What is fanciful is the idea that the Chief Medical Officer, or Chief Scientific Adviser, could or would go public and make statements that actively contradict Government policy as agreed by Ministers.

You are greatly over-complicating the situation to allow yourself to claim that the Government have been blameless at all times. Over lockdowns, PPE, billions for Dido Harding’s non-functioning contract tracing... always someone else to blame.

I think the government has been careful in its decision making. With hindsight, different decisions could have been made at times, but you could say that of other governments over the world.

This was a unique situation and we were dealing with the unknown. It’s all very well slagging off the government no matter what it does from the comfort of your own armchair, but I shudder to think about what a pig’s ear the other lot would have made of it. Captain Hindsight would have been facing the wrong direction throughout. Corbyn would have consulted Hamas.

At least this government has been decisive, and they have certainly come up trumps with vaccine procurement and the subsequent action to ensure prompt vaccination of the population.

Meanwhile, EU deaths are set to escalate with the start of a new wave that their population is fully exposed to.

Sephiroth 24-03-2021 19:59

Re: Coronavirus
 
I think the government has been careful in its decision making this year.

A year ago, they screwed up royally in not managing the care home situation.

As to the science officers, Boris knows that Witty is trusted by the people and this is what has made Boris become more circumspect.


jfman 24-03-2021 20:11

Re: Coronavirus
 
Quote:

Originally Posted by OLD BOY (Post 36075206)
I think the government has been careful in its decision making. With hindsight, different decisions could have been made at times, but you could say that of other governments over the world.

This was a unique situation and we were dealing with the unknown. It’s all very well slagging off the government no matter what it does from the comfort of your own armchair, but I shudder to think about what a pig’s ear the other lot would have made of it. Captain Hindsight would have been facing the wrong direction throughout. Corbyn would have consulted Hamas.

At least this government has been decisive, and they have certainly come up trumps with vaccine procurement and the subsequent action to ensure prompt vaccination of the population.

Meanwhile, EU deaths are set to escalate with the start of a new wave that their population is fully exposed to.

More tosh Old Boy.

Surely the EU can just "shield the vulnerable"? :dunce:

I see you've at least dropped that ludicrous tagline from beneath your user name.

The fact other governments could have made better decisions is neither here nor there to your original claim that I debunked - as I say it's a matter of public record - that they ignored SAGE advice on both lockdowns and this had a catastrophic impact modelled as tens of thousands of deaths.

Pierre 24-03-2021 20:15

Re: Coronavirus
 
Quote:

Originally Posted by 1andrew1 (Post 36075204)

Badly handled

Quote:

Test and trace
Agreed

Quote:

[*]Late lockdowns
I don’t think they are at fault for the lockdowns except perhaps for not locking down
London along with the rest of the country.

Quote:

[*]Christmas situation
if you are referring to the above London situation - agreed. Otherwise don’t know what you mean.

Quote:

[*]PPE procurement
considering it was a global issue they did alright.

Quote:

[*]Discharge of infected patients into nursing homes
Agreed

Quote:

[*]NHS pay rise
considering the hardships many of the citizens of the nation have suffered I think the NHS should have shut the flup up.

Quote:

[*]Dominic Cummings fiasco
blown out of all proportion by the MSM, he probably should have resigned though.

Quote:

[*]Not limiting inbound travel from overseas until fairly recently
there have been restrictions on inbound travel since the pandemic started.

pip08456 24-03-2021 22:39

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075212)
More tosh Old Boy.

Surely the EU can just "shield the vulnerable"? :dunce:

I see you've at least dropped that ludicrous tagline from beneath your user name.

The fact other governments could have made better decisions is neither here nor there to your original claim that I debunked - as I say it's a matter of public record - that they ignored SAGE advice on both lockdowns and this had a catastrophic impact modelled as tens of thousands of deaths.

So SAGE become the Government. What a stupid uninformed point of view.

The Government have to take in advice from many areas, attempt to weigh the pro's and con's and proceed accordingly.

Don't forget the SAGE advice was based on modelling since shown inept at best.

The current models for unlocking are not based on seasonal changes or actual vaccine take up so how can they be trusted?

Cases reducing, hospitalisation reducing, deaths reducing P-leasssse.

It has still yet to be proven that lockdowns actually work, they may in the short term to reduce pressure on hospitals but do they work overall?

Many people look to the far east to prove the effectivence of lockdowns/mask wearing without factoring in societal differences.

New Zealand is often brought up as an example but far easier to control the spread than any other 1st world country.

As Society is responsible for everything it does for and on behalf of itself why should any Government need to legislate what that society does?

Damien 24-03-2021 22:46

Re: Coronavirus
 
Quote:

Originally Posted by pip08456 (Post 36075220)
It has still yet to be proven that lockdowns actually work, they may in the short term to reduce pressure on hospitals but do they work overall?

Define what works means in this context? They clearly work in reducing pressure on hospitals as you say and they work in reducing transmission, cases and deaths as well.

Chris 24-03-2021 22:58

Re: Coronavirus
 
Lockdowns work overall - of course they do. It just depends what your “overall” is. The overall aim of a lockdown is to get transmission low enough for hospitals and the economy to function. The overall aim is not to eliminate covid from the population, regardless of what anyone says (Nicola Sturgeon liked to suggest she had a zero covid strategy in the early days ... she has quietly dropped that now). For quite some time now it has been acknowledged that a vaccine is the only actual exit route from the disruption to our lives.

pip08456 24-03-2021 23:02

Re: Coronavirus
 
Quote:

Originally Posted by Damien (Post 36075225)
Define what works means in this context? They clearly work in reducing pressure on hospitals as you say and they work in reducing transmission, cases and deaths as well.

My context is clear, you added "and" on as well. Now you have to show 12 months on where transmission and deaths has been reduced. Cases I have ignored as these could include asymptomaic or false positives. You got to love the Government for highlighting "cases" rather those who are actually suffering from it.
Helps SAGE with their scaremongering.

---------- Post added at 23:02 ---------- Previous post was at 23:00 ----------

Quote:

Originally Posted by Chris (Post 36075230)
Lockdowns work overall - of course they do. It just depends what your “overall” is. The overall aim of a lockdown is to get transmission low enough for hospitals and the economy to function. The overall aim is not to eliminate covid from the population, regardless of what anyone says (Nicola Sturgeon liked to suggest she had a zero covid strategy in the early days ... she has quietly dropped that now). For quite some time now it has been acknowledged that a vaccine is the only actual exit route from the disruption to our lives.

I'm sorry Chris, but I disagree and the answer will only come out afterwards. It only delayed the spread rightly to reduce NHS pressure.

OLD BOY 24-03-2021 23:17

Re: Coronavirus
 
Quote:

Originally Posted by jfman (Post 36075212)
More tosh Old Boy.

Surely the EU can just "shield the vulnerable"? :dunce:

I see you've at least dropped that ludicrous tagline from beneath your user name.

The fact other governments could have made better decisions is neither here nor there to your original claim that I debunked - as I say it's a matter of public record - that they ignored SAGE advice on both lockdowns and this had a catastrophic impact modelled as tens of thousands of deaths.

Shielding the vulnerable was perfectly sensible before we had the vaccine, because without that all we could do was slow it down.

As I said, there were other aspects over and above the Sage advice that needed to be taken account of. The government listened to ALL the arguments. Taking a different decision does not necessarily mean you ignored the advice. It was not taken for the reasons we will hear about when the review is forthcoming.

pip08456 25-03-2021 00:09

Re: Coronavirus
 
Quote:

Originally Posted by OLD BOY (Post 36075233)
Shielding the vulnerable was perfectly sensible before we had the vaccine, because without that all we could do was slow it down.

As I said, there were other aspects over and above the Sage advice that needed to be taken account of. The government listened to ALL the arguments. Taking a different decision does not necessarily mean you ignored the advice. It was not taken for the reasons we will hear about when the review is forthcoming.

You mean that review in at least 5yrs or do we have to wait for lockdown to end in 10 before it starts?

pip08456 25-03-2021 04:41

Re: Coronavirus
 
To those of you wondering about the Zoe app Maggy posted earlier (perhaps not this tread) here's more info.


jfman 25-03-2021 06:47

Re: Coronavirus
 
Quote:

Originally Posted by pip08456 (Post 36075220)
So SAGE become the Government. What a stupid uninformed point of view.

No worse than your ability to read, evidently.

Quote:

The Government have to take in advice from many areas, attempt to weigh the pro's and con's and proceed accordingly.
Indeed, it’s Government responsibility for the outcomes as I was stating to Old Boy. The Government tried to drag the “three week” lockdown to the Easter holidays as it’d have less economic impact. Not Whitty, not SAGE...

Quote:

Don't forget the SAGE advice was based on modelling since shown inept at best.
Has it?

Quote:

The current models for unlocking are not based on seasonal changes or actual vaccine take up so how can they be trusted?

Cases reducing, hospitalisation reducing, deaths reducing P-leasssse.

It has still yet to be proven that lockdowns actually work, they may in the short term to reduce pressure on hospitals but do they work overall?

Many people look to the far east to prove the effectivence of lockdowns/mask wearing without factoring in societal differences.

New Zealand is often brought up as an example but far easier to control the spread than any other 1st world country.

As Society is responsible for everything it does for and on behalf of itself why should any Government need to legislate what that society does?
Ah the “societal differences” trope.

As for your final point why have a speed limit? Require seatbelts? There’s a whole swathe of activity Governments don’t trust individuals with.

---------- Post added at 06:47 ---------- Previous post was at 06:44 ----------

Quote:

Originally Posted by OLD BOY (Post 36075233)
Shielding the vulnerable was perfectly sensible before we had the vaccine, because without that all we could do was slow it down.

As I said, there were other aspects over and above the Sage advice that needed to be taken account of. The government listened to ALL the arguments. Taking a different decision does not necessarily mean you ignored the advice. It was not taken for the reasons we will hear about when the review is forthcoming.

So European folk aren’t at risk despite a stalling vaccine rollout? It can only be one or the other, OB.

I eagerly await the review. The trailers for the bold Dom’s evidence have been good so far.

Maggy 25-03-2021 08:41

Re: Coronavirus
 
Quote:

Originally Posted by pip08456 (Post 36075237)
To those of you wondering about the Zoe app Maggy posted earlier (perhaps not this tread) here's more info.


Not me gov,unless the covid vaccination has affected my memory.

Hugh 25-03-2021 09:01

Re: Coronavirus
 
It was joglynne (I’ve been taking part too, along with 4.6 million others)

jonbxx 25-03-2021 09:31

Re: Coronavirus
 
Quote:

Originally Posted by pip08456 (Post 36075220)
It has still yet to be proven that lockdowns actually work, they may in the short term to reduce pressure on hospitals but do they work overall?

...

As Society is responsible for everything it does for and on behalf of itself why should any Government need to legislate what that society does?

The experience from the Spanish Flu says yes, lockdowns work - https://www.nationalgeographic.com/h...ic-coronavirus (more formal study here - https://www.pnas.org/content/104/18/7582 )

On your second comment, it falls down when public health is involved unless society provides its' own healthcare service. It's governments role to keep us safe. It's why we have the police, army, etc. If suggesting and asking nicely to act safely doesn't work, then governments legislate. It's why we have speed limits. As I have said before, we in the UK are 'soft' when it comes to healthcare as we know that the NHS will always be there if we mess up. If that safety net weren't present, people would be a lot more careful!

Libertariansim like communism is a nice idea on paper but doesn't work in the real world.

pip08456 25-03-2021 10:12

Re: Coronavirus
 
Quote:

Originally Posted by Hugh (Post 36075241)
It was joglynne (I’ve been taking part too, along with 4.6 million others)

Ahhh, how right you are.

Sorry Maggy.


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