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This Brazilian variant seems to be like a 'cut and shut' of the UK and South African variants around the business parts of the spike (amino acids 400-600ish)
Here are the three compared - https://twitter.com/sailorrooscout/s...75542097825792 Considering most of the vaccines out there work well against both the UK and South Africa types, I wouldn't panic just yet. |
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Which vaccines work well against both the UK and South African types? |
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You couldn't make it up - except in the perfidious and vindictive EU.
Here is the paywalled link plus a useful quote. https://www.telegraph.co.uk/news/202...aign=DM1343081 Quote:
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Nice to see your even-handed comments on this.
They made an stupid error, realised it, and are correcting it - this is a common occurrence, not the end of earth or a massive conspiracy against the British. The throbbing vein on your forehead must be a sight to behold.... "Pig headed, self righteous, and pompous" - oh, the irony... |
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I'm expecting delays in easing lockdown due to the Brazilian variant.
My dad and I are hoping to be able to sit in my sister garden on the 27th which will be her 50th. Even though hugging won't be allowed, at least we can sit in their garden and living room, but I'm expecting this to be cancelled. |
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It’s only mildly entertaining watching German experts scratching their heads and wondering how the official denigration of a vaccine has led to a plummet in confidence and refusals to accept it. Mostly it’s tragic because they now have quantities of the Oxford-AstraZeneca vaccine sitting in fridges rather than in the arms of people who may now get very sick or even die of covid. |
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Why would I wish to be even-handed in this matter? Their stupid error could lead to hundreds of unnecessary deaths. I repeat, the EU, France and Germany (governments) are pig headed, self righteous and pompous. If you can't see that then you're deluding yourself. |
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At the time of submission, there was insufficient data to support the effectiveness of the AZ vaccine in over 65s. There is no reason to expect the reaction over over 65s to be significantly different based on the reactions to COVID infections but also no hard evidence to say it will work. That's good enough for an Emergency Use Authorisation but probably not for a Conditional Market Authorisation. Probably explained better by people with brains much bigger than mine here - https://www.sciencemediacentre.org/e...for-under-65s/ |
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There was actually perfectly adequate scientific data to support emergency use authorisation, and we are after all in an emergency. The phase 3 trials lacked sufficient test subjects in that age group to produce definitive data but there was ample data on antibody response and equally ample understanding that it was most likely this would translate into comparable vaccine efficacy in that group. Given the problem Germany and France have with anti-vax movements they more than anyone should have understood that you can’t simply say you’re following the science as if science exists in a cultureless vacuum. How the science is communicated and how it is used politically are vitally important - as Germany is now discovering to its cost. |
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Covid vaccines cut risk of serious illness by 80%
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The German public won't be impressed. |
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Where there's a stronger anti-vaccine sentiment, I don't think 'it will probably work in over 65s' is a strong argument to increase vaccine uptake. We have lots of arguments that it hasn't been tested enough in this country. The fact that efficacy in over 65s was assumed rather than proved was somewhat glossed over. ---------- Post added at 18:31 ---------- Previous post was at 18:28 ---------- Quote:
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At the very least, the existing vaccines should prevent people from getting so ill they end up in hospital, so there’s no reason to adjust the ‘roadmap’. By the autumn, the successor vaccine will be able to tackle the variants much more effectively. |
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Germany, population 84 million, COVID deaths 72,000 (1 in 1177) U.K., population 68 million, COVID deaths 123,000 (1 in 553) Our COVID death rate is more than twice Germany’s... |
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You know perfectly well I was referring to the excess deaths likely to be caused by the public reaction to government advice on the AZ vaccine. I repeat, the regulator has now rescinded that advice. |
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Plenty of countries will have lower death rates, but they will tend to be ones that had a LOWER number of infections and hospitalisations in the first place. |
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Persuade us that it is an unfair comparison. |
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Parts of World have had very few or no cases. They haven't done anything special to have lower death rates. If there are a lot of big gatherings at funerals, marriages, parties, religious gatherings, etc, then there are going to be a lot of cases, and therefore deaths. Eg In the UK and New York(and perhaps more generally in the world), Orthodox Jews have been disproportionately affected. That is because they insist on constantly having big gatherings, not wearing masks, and not social distancing. Their fault, not any governments. Ethiopia has a death rate a fraction of that of most countries. Why is that? A better health system? Extremely unlikely, or would it be fewer cases, and fewer people spreading it around. |
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Everyone followed the science, right up to the point when a political decision had to be taken. Which is why “they followed the science” is an inadequate explanation for the decisions that have been made. |
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Is the "science" not that they have (or at least were due) more of the Pfizer vaccine and we do not?
All things being equal based on the data available there'd be no reason to risk the AZ vaccine on groups it hadn't been tested on when you could offer them Pfizer, concentrating AZ on groups it had been tested on. As it stands both suppliers let the EU down, but that doesn't make it an unsound judgement based on the circumstances. Despite the emergency the United States haven't approved the AZ vaccine at all. South Africa have handed theirs to neighbouring countries instead of distributing them. It seems somewhat bizarre that the UK are seeking vindication for their own decisions from the EU of all people. |
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Of course, they may also have thought it was politically helpful to be able to talk down the British vaccine thereby enhancing the status of the German one. There is no doubt the EU’s procurement shortcomings reflect poorly on member states who supported it - especially those that abandoned their own promising procurement programmes in order to take part. Whatever’s the case, they failed to calculate was the lasting damage they were doing to the reputation of the AstraZeneca vaccine and how this would start to compromise their vaccination programme among younger adults who would still be offered it. This is what senior experts in Germany are now starting to acknowledge. |
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Germany is in the unique position (I think) of some states offering a choice to individuals. If uptake is that much of a concern they should simply withdraw the choice.
AstraZeneca’s own press release from December is enough that (again all things being equal) a rational individual would pick the higher performing vaccine. There’s no individual benefit in taking a lesser performing vaccine - it’s a collective one. ---------- Post added at 22:26 ---------- Previous post was at 22:23 ---------- Quote:
Had emerging data gone the other way they’d have to redo everyone given an AZ vaccine with a Pfizer one, essentially wasting tens of millions of doses in the process slowing down the vaccination programme and leaving the most vulnerable at risk for longer. It’s taken what, a month for data to come from the UK? It’s hard to see the political benefit of u-turning after 4 weeks, which if it was the unambiguous science they would have known to be inevitable. |
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Forgive me if this has already been posted today but the Public Health England data published today agrees with that already published in Scotland a week or so ago. Either the Pfizer or AZ jab reduces hospitalisations amongst those aged over 80 by more than 80%; after a single dose the AZ jab is more effective than the Pfizer one.
https://www.bbc.co.uk/news/health-56240220 Rejoice at that news. Unless of course we’re still being conned by the propaganda apparatus of the British State. :dozey: |
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But to state that if you have a lower number of infections in the first place as if this is somewhat dealt out randomly is flawed. |
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The most obvious question is the methodology that gave them their sample size, which has a test positivity rate at over 60% for the unvaccinated 80+ year olds. This at face value seems high. I’m surprised we don’t have something using population wide data by now breaking down cases, hospitalisations and deaths by age tracking back to the start of vaccinations. All of these figures will be reducing due to lockdown but a nice graph should show a clear and increasing effect of the vaccine in older age groups compared to the population as a whole. ---------- Post added at 04:07 ---------- Previous post was at 04:06 ---------- Quote:
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If there's an alternative that is proven to be effective in over 65s rather than inferred, then the pressure is off to take the chance, however small. |
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5 taxis and several cars outside a nearby house piqued police interest early this morning. All in the "high risk" category.
Immigration officers are there now. |
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I've been catching up on some work related news websites to see what's new and found this article - Top 7 Best Selling COVID-19 Vaccines and Drugs of 2020 . This has 2020 sales figures and forecasts for 2021.
There's a lot of money out there for the pharma companies (and their suppliers :D ) |
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There’s a decent infographic here, detailing what unit price the pharma companies are selling covid vaccines at: https://www.bbc.co.uk/news/business-55170756 |
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So I guess the West is winning on soft diplomacy thanks to the two $3 vaccines. |
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The most important coronavirus information you need today - https://onewayroadtobeer.com/
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Except for viewers in Scotland :(
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Aye. :mad: |
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Let me think about it....:scratch: |
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A third study has further substantiated the claim that a single dose of either the Pfizer or the AZ vaccine reduces hospitalisation by 80% in those aged over 80.
https://www.bbc.co.uk/news/health-56267473 I can't help thinking that this latest piece of research still won't be enough for anyone still desperately hoping that the British government and the devolved administrations made a horrible mistake in opting for the 12-week dosage gap... |
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I'm still yet to see an explanation for the test positivity rate of over 60% for unvaccinated over 70s in the last yet to be peer reviewed study. Obviously, when peer reviewed I'm sure glaring errors (or explainations) will get suitable prominence on the BBC website and other mainstream press. I guess there's also the question of who is funding such studies, and why, when they wouldn't stand up to scientific scrutiny at this stage for any medical authority seeking to make regulatory changes (e.g. to the quality standard of randomised control trials) but they do make good press releases. :) |
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The majority of NHS testing capacity is for those with symptoms booking a test and positivity never gets that high. Even when at the height of the first wave when testing was only for those with symptoms positivity never got that high. |
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The best I can find is figure 11a in https://assets.publishing.service.go...ummary_w17.pdf which shows that the positivity rate increases significantly with age. (And that's of people with any respiratory or flu-like infection, not just those COVID symptomatic) |
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It’s hard to avoid the conclusion that you think there’s a deep State propaganda operation in motion here, and that yes, you do need the vaccination policy to fail and this epic display of straw-clutching proves it. It looks to me like all of the above is easier for you to swallow than the idea that el gov may have made a good call and a series of suitably qualified experts are proving it with sound science that has been fairly and broadly reported by a range of news media. |
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The work was funded directly or indirectly in the case of the Universities by the Government. |
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Well, it seems the massive British disinformation effort has been so successful, the Germans think
Hurrah for the BBC! </SATIRE> https://www.bbc.co.uk/news/world-europe-56275342 Quote:
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Notably the recommendations for the Pfizer vaccine are unchanged and 12 weeks remains an “up to” figure. I’m sure they’ll be watching closely as the devolved nations have clearly diverged on their policies with England lagging behind on second doses at 13%, NI and Scotland at around 25% and Wales over 60% of those issued yesterday. All following the same science too. |
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Obviously, not a great situation for anyone. Would be interesting to know what Australia's contract says and when it was signed.
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It's good that data has become available that sticks two fingers up to the vindictive EU but which has put lives at risk in their member countries. ---------- Post added at 18:33 ---------- Previous post was at 18:31 ---------- Quote:
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So why weren’t the USA, Switzerland, and Canada "vindictive countries which put lives at risk"?
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What's held it back is sovereign EU countries placing more restrictions on its use. Furthermotre countries like France are traditionally more vaccine-averse than the UK. Plus AstraZeneca is not an experienced vaccine manufacturer (unlike say Merck) so made a few submission mistakes. |
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Australia should be coming online with home grown AZ vaccine soon. It's going to made at CSL near Melbourne. Here's a really nice article on how the vaccine is made - https://www.abc.net.au/news/science/...uring/13140104
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The home-grown manufacturing probably explains in part Australia's muted reaction to Italy's export ban. |
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So, the EU based factories making the AZ vaccine cannot produce enough to meet demand, they can go whistle for UK produced vaccine. Australia based factories making the AZ vaccine cannot produce enough to meet demand, fill your boots...
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Let the emotive vitriolic diatribes begin! :D |
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And please don't attribute "perfidious ****" to me. Apology expected. |
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Do we now campaign for the USA to approve the AZ vaccine or are they allowed to continue clinical trials?
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Personally I don't care whether the German or the French governments approve of the AstraZeneca vaccine or not, except in the sense that it's mildly entertaining watching them sabotage their own vaccination programmes even as they desperately try to big up European endeavour post-Brexit. Whether or not individual national medicines agencies have acted truly without political interference is neither here nor there. The politically-inspired messaging that followed those decisions in certain key EU member states is the reason they are having vaccine uptake problems now. Over in the USA, the FDA is being famously slow. It is well known for shredding conclusions offered to them by drug companies, going back to the raw data, examining it closely and forming conclusions of its own from scratch. This takes time. Are they prioritising domestic vaccine producers as well? Probably. Do I care ... no. Italy's export refusal is the more interesting development this week. For my money that is more likely to have a long-term effect on levels of trust between nations, although I also note Australia doesn't seem enormously concerned. This is most likely due to their low infection rates and the fact that domestic production of AZ is about to begin. |
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Several months ago I joked (sort of) that we're only a few steps away from men in long leather trench coats and wire rimmed spectacles stopping you and demanding to see your "papers"
Well we just took another step closer. https://news.sky.com/story/covid-19-...-fine-12236847 |
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I dont think checking you have a valid reason is unreasonable.
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Did not expect to see this, would have expected UK Covid 19 death rate to be on the decline now.
https://www.cableforum.uk/board/show...1#post36073221 |
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This is making you carry around a document authorising you to travel. This is the government saying we don't trust any of you, you must explain why you are travelling in writing and if you don't we'll fine you, oh and yes don't worry you do live in a free society. ---------- Post added at 17:32 ---------- Previous post was at 17:31 ---------- Quote:
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A visa is issued by the destination state usually describing the terms of your visit. The U.K. Gov doesn’t issue a visa for me to visit India, the Government does. The U.K. government issues me with a Passport and I make my own decision on where to go and when, within the boundaries of the law. |
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I would imagine most people travelling from the UK would need to have documentation showing their trip is necessary anyway. Certainly my work colleagues need it to travel across Europe and come back without quarantine/self isolation. They have to fill in an online form to get a letter from our work so it's just one more form to fill out.
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Looks like the US's lengthy process in approving the AstraZeneca vaccine could work to the advantage of the EU. They're in talks to permit supplies of the AstraZeneca vaccine to be exported from the US. A bit cheeky considering the EU was happy to let Italy bloc exports to Australia. ;)
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Fans of a football club in glasgow prove themselves to be selfish, thick and complete assholes :td:
You really hope they all get covid and suffer. :mad: IDIOTS |
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It's happened to both of the big clubs in Glasgow recently, you also seem to forget that Liverpool fans did exactly this last season when they won the EPL, did you post a comment about that? Just asking. |
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Should we and other countries vaccinate those in poor countries? None of us is safe until we are all safe, unless we completely close our borders.
An interesting question posed by this mornings Hardtalk programme: https://www.bbc.co.uk/programmes/m000t3l0 |
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I see they always trot out the "lives at risk" excuse (when it suits) - its a very small risk, and one we have been happy to accept in previous years without blinking. Also, strange how all those BLM [and other] protests last year were not condemmed the same way .... |
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